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Local epigenomic state cannot discriminate interacting and non-interacting enhancer–promoter pairs with high accuracy
We report an experimental design issue in recent machine learning formulations of the enhancer-promoter interaction problem arising from the fact that many enhancer-promoter pairs share features. Cross-fold validation schemes which do not correctly separate these feature sharing enhancer-promoter pa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298642/ https://www.ncbi.nlm.nih.gov/pubmed/30562350 http://dx.doi.org/10.1371/journal.pcbi.1006625 |