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Late vertebral side effects in long-term survivors of irradiated childhood brain tumor

PURPOSE: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study...

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Autores principales: Jussila, Miro-Pekka, Remes, Tiina, Anttonen, Julia, Harila-Saari, Arja, Niinimäki, Jaakko, Pokka, Tytti, Koskenkorva, Päivi, Sutela, Anna, Toiviainen-Salo, Sanna, Arikoski, Pekka, Riikonen, Pekka, Arola, Mikko, Lähteenmäki, Päivi, Sirkiä, Kirsti, Rantala, Heikki, Suo-Palosaari, Maria, Ojaniemi, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298650/
https://www.ncbi.nlm.nih.gov/pubmed/30562369
http://dx.doi.org/10.1371/journal.pone.0209193
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author Jussila, Miro-Pekka
Remes, Tiina
Anttonen, Julia
Harila-Saari, Arja
Niinimäki, Jaakko
Pokka, Tytti
Koskenkorva, Päivi
Sutela, Anna
Toiviainen-Salo, Sanna
Arikoski, Pekka
Riikonen, Pekka
Arola, Mikko
Lähteenmäki, Päivi
Sirkiä, Kirsti
Rantala, Heikki
Suo-Palosaari, Maria
Ojaniemi, Marja
author_facet Jussila, Miro-Pekka
Remes, Tiina
Anttonen, Julia
Harila-Saari, Arja
Niinimäki, Jaakko
Pokka, Tytti
Koskenkorva, Päivi
Sutela, Anna
Toiviainen-Salo, Sanna
Arikoski, Pekka
Riikonen, Pekka
Arola, Mikko
Lähteenmäki, Päivi
Sirkiä, Kirsti
Rantala, Heikki
Suo-Palosaari, Maria
Ojaniemi, Marja
author_sort Jussila, Miro-Pekka
collection PubMed
description PURPOSE: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors. METHODS: 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant’s semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry. RESULTS: 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation-induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population. CONCLUSION: Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation.
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spelling pubmed-62986502018-12-28 Late vertebral side effects in long-term survivors of irradiated childhood brain tumor Jussila, Miro-Pekka Remes, Tiina Anttonen, Julia Harila-Saari, Arja Niinimäki, Jaakko Pokka, Tytti Koskenkorva, Päivi Sutela, Anna Toiviainen-Salo, Sanna Arikoski, Pekka Riikonen, Pekka Arola, Mikko Lähteenmäki, Päivi Sirkiä, Kirsti Rantala, Heikki Suo-Palosaari, Maria Ojaniemi, Marja PLoS One Research Article PURPOSE: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors. METHODS: 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant’s semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry. RESULTS: 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation-induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population. CONCLUSION: Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation. Public Library of Science 2018-12-18 /pmc/articles/PMC6298650/ /pubmed/30562369 http://dx.doi.org/10.1371/journal.pone.0209193 Text en © 2018 Jussila et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jussila, Miro-Pekka
Remes, Tiina
Anttonen, Julia
Harila-Saari, Arja
Niinimäki, Jaakko
Pokka, Tytti
Koskenkorva, Päivi
Sutela, Anna
Toiviainen-Salo, Sanna
Arikoski, Pekka
Riikonen, Pekka
Arola, Mikko
Lähteenmäki, Päivi
Sirkiä, Kirsti
Rantala, Heikki
Suo-Palosaari, Maria
Ojaniemi, Marja
Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title_full Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title_fullStr Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title_full_unstemmed Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title_short Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
title_sort late vertebral side effects in long-term survivors of irradiated childhood brain tumor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298650/
https://www.ncbi.nlm.nih.gov/pubmed/30562369
http://dx.doi.org/10.1371/journal.pone.0209193
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