Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

Synthetic lethality results when mutant KRAS and EGFR proteins are co-expressed in human lung adenocarcinoma (LUAD) cells, revealing the biological basis for mutual exclusivity of KRAS and EGFR mutations. We have now defined the biochemical events responsible for the toxic effects by combining pharm...

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Detalles Bibliográficos
Autores principales: Unni, Arun M, Harbourne, Bryant, Oh, Min Hee, Wild, Sophia, Ferrarone, John R, Lockwood, William W, Varmus, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298772/
https://www.ncbi.nlm.nih.gov/pubmed/30475204
http://dx.doi.org/10.7554/eLife.33718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298772/
https://www.ncbi.nlm.nih.gov/pubmed/30475204
http://dx.doi.org/10.7554/eLife.33718

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