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Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons

In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons. However, how PNNs tune cortical function and plasticity is unknown. We found that PNNs modulated the gain of visual respo...

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Autores principales: Faini, Giulia, Aguirre, Andrea, Landi, Silvia, Lamers, Didi, Pizzorusso, Tommaso, Ratto, Gian Michele, Deleuze, Charlotte, Bacci, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298774/
https://www.ncbi.nlm.nih.gov/pubmed/30561327
http://dx.doi.org/10.7554/eLife.41520
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author Faini, Giulia
Aguirre, Andrea
Landi, Silvia
Lamers, Didi
Pizzorusso, Tommaso
Ratto, Gian Michele
Deleuze, Charlotte
Bacci, Alberto
author_facet Faini, Giulia
Aguirre, Andrea
Landi, Silvia
Lamers, Didi
Pizzorusso, Tommaso
Ratto, Gian Michele
Deleuze, Charlotte
Bacci, Alberto
author_sort Faini, Giulia
collection PubMed
description In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons. However, how PNNs tune cortical function and plasticity is unknown. We found that PNNs modulated the gain of visual responses and γ-oscillations in the adult mouse visual cortex in vivo, consistent with increased interneuron function. Removal of PNNs in adult V1 did not affect GABAergic neurotransmission from PV cells, nor neuronal excitability in layer 4. Importantly, PNN degradation coupled to sensory input potentiated glutamatergic thalamic synapses selectively onto PV cells. In the absence of PNNs, increased thalamic PV-cell recruitment modulated feed-forward inhibition differently on PV cells and pyramidal neurons. These effects depended on visual input, as they were strongly attenuated by monocular deprivation in PNN-depleted adult mice. Thus, PNNs control visual processing and plasticity by selectively setting the strength of thalamic recruitment of PV cells.
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spelling pubmed-62987742018-12-18 Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons Faini, Giulia Aguirre, Andrea Landi, Silvia Lamers, Didi Pizzorusso, Tommaso Ratto, Gian Michele Deleuze, Charlotte Bacci, Alberto eLife Neuroscience In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons. However, how PNNs tune cortical function and plasticity is unknown. We found that PNNs modulated the gain of visual responses and γ-oscillations in the adult mouse visual cortex in vivo, consistent with increased interneuron function. Removal of PNNs in adult V1 did not affect GABAergic neurotransmission from PV cells, nor neuronal excitability in layer 4. Importantly, PNN degradation coupled to sensory input potentiated glutamatergic thalamic synapses selectively onto PV cells. In the absence of PNNs, increased thalamic PV-cell recruitment modulated feed-forward inhibition differently on PV cells and pyramidal neurons. These effects depended on visual input, as they were strongly attenuated by monocular deprivation in PNN-depleted adult mice. Thus, PNNs control visual processing and plasticity by selectively setting the strength of thalamic recruitment of PV cells. eLife Sciences Publications, Ltd 2018-12-18 /pmc/articles/PMC6298774/ /pubmed/30561327 http://dx.doi.org/10.7554/eLife.41520 Text en © 2018, Faini et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Faini, Giulia
Aguirre, Andrea
Landi, Silvia
Lamers, Didi
Pizzorusso, Tommaso
Ratto, Gian Michele
Deleuze, Charlotte
Bacci, Alberto
Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title_full Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title_fullStr Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title_full_unstemmed Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title_short Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons
title_sort perineuronal nets control visual input via thalamic recruitment of cortical pv interneurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298774/
https://www.ncbi.nlm.nih.gov/pubmed/30561327
http://dx.doi.org/10.7554/eLife.41520
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