Cargando…
Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes
For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding of the mechanisms underlying disease pathology and to identify genetic biomarkers predictive of disease outco...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298887/ https://www.ncbi.nlm.nih.gov/pubmed/30554485 http://dx.doi.org/10.3349/ymj.2019.60.1.1 |
_version_ | 1783381373355032576 |
---|---|
author | Park, Jong-Sook Son, Ji-Hye Park, Choon-Sik Chang, Hun Soo |
author_facet | Park, Jong-Sook Son, Ji-Hye Park, Choon-Sik Chang, Hun Soo |
author_sort | Park, Jong-Sook |
collection | PubMed |
description | For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding of the mechanisms underlying disease pathology and to identify genetic biomarkers predictive of disease outcomes. Various methods have been used to achieve these objectives, including linkage analysis, candidate gene polymorphism analysis, and genome-wide association studies (GWAS); however, the degree to which genetic variants contribute to asthma pathogenesis has proven to be much less significant than originally expected. Subsequent application of GWAS to well-defined phenotypes, such as occupational asthma and non-steroidal anti-inflammatory drugexacerbated respiratory diseases, has overcome some of these limitations, although with only partial success. Recently, a combinatorial analysis of single nucleotide polymorphisms (SNPs) identified by GWAS has been used to develop sets of genetic markers able to more accurately stratify asthma subtypes. In this review, we discuss the implications of the identified SNPs in diagnosis of asthma and its subtypes and the progress being made in combinatorial analysis of genetic variants. |
format | Online Article Text |
id | pubmed-6298887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-62988872019-01-01 Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes Park, Jong-Sook Son, Ji-Hye Park, Choon-Sik Chang, Hun Soo Yonsei Med J Review Article For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding of the mechanisms underlying disease pathology and to identify genetic biomarkers predictive of disease outcomes. Various methods have been used to achieve these objectives, including linkage analysis, candidate gene polymorphism analysis, and genome-wide association studies (GWAS); however, the degree to which genetic variants contribute to asthma pathogenesis has proven to be much less significant than originally expected. Subsequent application of GWAS to well-defined phenotypes, such as occupational asthma and non-steroidal anti-inflammatory drugexacerbated respiratory diseases, has overcome some of these limitations, although with only partial success. Recently, a combinatorial analysis of single nucleotide polymorphisms (SNPs) identified by GWAS has been used to develop sets of genetic markers able to more accurately stratify asthma subtypes. In this review, we discuss the implications of the identified SNPs in diagnosis of asthma and its subtypes and the progress being made in combinatorial analysis of genetic variants. Yonsei University College of Medicine 2019-01-01 2018-12-13 /pmc/articles/PMC6298887/ /pubmed/30554485 http://dx.doi.org/10.3349/ymj.2019.60.1.1 Text en © Copyright: Yonsei University College of Medicine 2019 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, Jong-Sook Son, Ji-Hye Park, Choon-Sik Chang, Hun Soo Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title | Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title_full | Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title_fullStr | Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title_full_unstemmed | Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title_short | Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes |
title_sort | clinical implications of single nucleotide polymorphisms in diagnosis of asthma and its subtypes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298887/ https://www.ncbi.nlm.nih.gov/pubmed/30554485 http://dx.doi.org/10.3349/ymj.2019.60.1.1 |
work_keys_str_mv | AT parkjongsook clinicalimplicationsofsinglenucleotidepolymorphismsindiagnosisofasthmaanditssubtypes AT sonjihye clinicalimplicationsofsinglenucleotidepolymorphismsindiagnosisofasthmaanditssubtypes AT parkchoonsik clinicalimplicationsofsinglenucleotidepolymorphismsindiagnosisofasthmaanditssubtypes AT changhunsoo clinicalimplicationsofsinglenucleotidepolymorphismsindiagnosisofasthmaanditssubtypes |