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Exercise in Myositis

PURPOSE OF THE REVIEW: A growing body of evidence supports exercise as a very important part of the treatment for adult patients with idiopathic inflammatory myopathies (IIM). This review mainly focuses on exercise studies published during the last 2 years in adult myositis. RECENT FINDINGS: During...

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Autor principal: Alexanderson, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299050/
https://www.ncbi.nlm.nih.gov/pubmed/30613464
http://dx.doi.org/10.1007/s40674-018-0113-3
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author Alexanderson, Helene
author_facet Alexanderson, Helene
author_sort Alexanderson, Helene
collection PubMed
description PURPOSE OF THE REVIEW: A growing body of evidence supports exercise as a very important part of the treatment for adult patients with idiopathic inflammatory myopathies (IIM). This review mainly focuses on exercise studies published during the last 2 years in adult myositis. RECENT FINDINGS: During the last couple of years, new publications present further evidence for intensive endurance exercise as an anti-inflammatory treatment inducing muscle growth and improving mitochondrial function compared a non-exercising control group. Further, blood-flow restricted resistance training was effective to maintain muscle strength compared to a non-exercising control group which lost a mean of 9.2% in quadriceps strength over 3 months in inclusion body myositis. Another study evaluates the effects of intra-muscular injections of an isoform of follistatin (FS344) by AAV1 in combination with exercise in a small group of patients with inclusion body myositis. An improvement in physical capacity was associated to higher exercise levels. Less is known about exercise effects in patients with recent onset, active polymyositis, and dermatomyositis. SUMMARY: All studies report safety of exercise in all types and stages of myositis and exercise could now be considered as medicine. It is recommended to initiate exercise on a low intensity under supervision of a physical therapist with regular follow-up and progression of intensity over time.
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spelling pubmed-62990502019-01-03 Exercise in Myositis Alexanderson, Helene Curr Treatm Opt Rheumatol Other CTD: Inflammatory Myopathies and Sjögren's (P Basharat, Section Editor) PURPOSE OF THE REVIEW: A growing body of evidence supports exercise as a very important part of the treatment for adult patients with idiopathic inflammatory myopathies (IIM). This review mainly focuses on exercise studies published during the last 2 years in adult myositis. RECENT FINDINGS: During the last couple of years, new publications present further evidence for intensive endurance exercise as an anti-inflammatory treatment inducing muscle growth and improving mitochondrial function compared a non-exercising control group. Further, blood-flow restricted resistance training was effective to maintain muscle strength compared to a non-exercising control group which lost a mean of 9.2% in quadriceps strength over 3 months in inclusion body myositis. Another study evaluates the effects of intra-muscular injections of an isoform of follistatin (FS344) by AAV1 in combination with exercise in a small group of patients with inclusion body myositis. An improvement in physical capacity was associated to higher exercise levels. Less is known about exercise effects in patients with recent onset, active polymyositis, and dermatomyositis. SUMMARY: All studies report safety of exercise in all types and stages of myositis and exercise could now be considered as medicine. It is recommended to initiate exercise on a low intensity under supervision of a physical therapist with regular follow-up and progression of intensity over time. Springer International Publishing 2018-11-23 2018 /pmc/articles/PMC6299050/ /pubmed/30613464 http://dx.doi.org/10.1007/s40674-018-0113-3 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Other CTD: Inflammatory Myopathies and Sjögren's (P Basharat, Section Editor)
Alexanderson, Helene
Exercise in Myositis
title Exercise in Myositis
title_full Exercise in Myositis
title_fullStr Exercise in Myositis
title_full_unstemmed Exercise in Myositis
title_short Exercise in Myositis
title_sort exercise in myositis
topic Other CTD: Inflammatory Myopathies and Sjögren's (P Basharat, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299050/
https://www.ncbi.nlm.nih.gov/pubmed/30613464
http://dx.doi.org/10.1007/s40674-018-0113-3
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