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Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain

Lysophosphatidic acid or LPA is a phospholipid which has been extensively linked to the generation and maintenance of pain. Several ion channels have also been shown to participate in this pathological process but the link between LPA and these proteins in pain has just recently gained interest. In...

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Autores principales: Juárez-Contreras, Rebeca, Rosenbaum, Tamara, Morales-Lázaro, Sara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299067/
https://www.ncbi.nlm.nih.gov/pubmed/30618613
http://dx.doi.org/10.3389/fnmol.2018.00462
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author Juárez-Contreras, Rebeca
Rosenbaum, Tamara
Morales-Lázaro, Sara L.
author_facet Juárez-Contreras, Rebeca
Rosenbaum, Tamara
Morales-Lázaro, Sara L.
author_sort Juárez-Contreras, Rebeca
collection PubMed
description Lysophosphatidic acid or LPA is a phospholipid which has been extensively linked to the generation and maintenance of pain. Several ion channels have also been shown to participate in this pathological process but the link between LPA and these proteins in pain has just recently gained interest. In this respect, the field has advanced by determining the molecular mechanisms by which LPA promotes changes in the function of some ion channels. While some of the actions of LPA include modulation of signaling pathways associated to its specific receptors, other include a direct interaction with a region in the structure of ion channels to affect their gating properties. Here, we focus on the known effects of LPA on some transient receptor potential, sodium, potassium, and calcium channels. As the field moves forward, mechanisms are unveiled with the hope of understanding the underlying causes of pain in order to target these and control this pathophysiological state.
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spelling pubmed-62990672019-01-07 Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain Juárez-Contreras, Rebeca Rosenbaum, Tamara Morales-Lázaro, Sara L. Front Mol Neurosci Neuroscience Lysophosphatidic acid or LPA is a phospholipid which has been extensively linked to the generation and maintenance of pain. Several ion channels have also been shown to participate in this pathological process but the link between LPA and these proteins in pain has just recently gained interest. In this respect, the field has advanced by determining the molecular mechanisms by which LPA promotes changes in the function of some ion channels. While some of the actions of LPA include modulation of signaling pathways associated to its specific receptors, other include a direct interaction with a region in the structure of ion channels to affect their gating properties. Here, we focus on the known effects of LPA on some transient receptor potential, sodium, potassium, and calcium channels. As the field moves forward, mechanisms are unveiled with the hope of understanding the underlying causes of pain in order to target these and control this pathophysiological state. Frontiers Media S.A. 2018-12-12 /pmc/articles/PMC6299067/ /pubmed/30618613 http://dx.doi.org/10.3389/fnmol.2018.00462 Text en Copyright © 2018 Juárez-Contreras, Rosenbaum and Morales-Lázaro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Juárez-Contreras, Rebeca
Rosenbaum, Tamara
Morales-Lázaro, Sara L.
Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title_full Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title_fullStr Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title_full_unstemmed Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title_short Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain
title_sort lysophosphatidic acid and ion channels as molecular mediators of pain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299067/
https://www.ncbi.nlm.nih.gov/pubmed/30618613
http://dx.doi.org/10.3389/fnmol.2018.00462
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