HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

Endoplasmic Reticulum (ER) stress of alveolar epithelial cells (AECs) is recognized as a key event of cell dysfunction in pulmonary fibrosis (PF). However, the mechanisms leading to AECs ER stress and ensuing unfolded protein response (UPR) pathways in idiopathic PF (IPF) remain unclear. We hypothes...

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Detalles Bibliográficos
Autores principales: Delbrel, Eva, Soumare, Abdoulaye, Naguez, Adnan, Label, Rabab, Bernard, Olivier, Bruhat, Alain, Fafournoux, Pierre, Tremblais, Geoffrey, Marchant, Dominique, Gille, Thomas, Bernaudin, Jean-François, Callard, Patrice, Kambouchner, Marianne, Martinod, Emmanuel, Valeyre, Dominique, Uzunhan, Yurdagül, Planès, Carole, Boncoeur, Emilie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299072/
https://www.ncbi.nlm.nih.gov/pubmed/30560874
http://dx.doi.org/10.1038/s41598-018-36063-2

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