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A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

Botulinum neurotoxin (BoNT) delivers its protease domain across the vesicle membrane to enter the neuronal cytosol upon vesicle acidification. This process is mediated by its translocation domain (H(N)), but the molecular mechanism underlying membrane insertion of H(N) remains poorly understood. Her...

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Detalles Bibliográficos
Autores principales:	Lam, Kwok-ho, Guo, Zhuojun, Krez, Nadja, Matsui, Tsutomu, Perry, Kay, Weisemann, Jasmin, Rummel, Andreas, Bowen, Mark E., Jin, Rongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299077/ https://www.ncbi.nlm.nih.gov/pubmed/30560862 http://dx.doi.org/10.1038/s41467-018-07789-4

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