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Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structur...

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Detalles Bibliográficos
Autores principales:	Li, Zhihai, Song, Shuo, He, Maozhou, Wang, Daning, Shi, Jingjie, Liu, Xinlin, Li, Yunbing, Chi, Xin, Wei, Shuangping, Yang, Yurou, Wang, Zhiping, Li, Jinjin, Qian, Huilian, Yu, Hai, Zheng, Qingbing, Yan, Xiaodong, Zhao, Qinjian, Zhang, Jun, Gu, Ying, Li, Shaowei, Xia, Ningshao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299097/ https://www.ncbi.nlm.nih.gov/pubmed/30560935 http://dx.doi.org/10.1038/s41467-018-07199-6

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