Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with...

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Autores principales: Liu, Yi-Hsia, Mölzer, Christine, Milne, Gillian C., Kuffová, Lucia, Forrester, John V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Medicine and Dentistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299122/
https://www.ncbi.nlm.nih.gov/pubmed/30581918
http://dx.doi.org/10.1016/j.dib.2018.12.007
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author Liu, Yi-Hsia
Mölzer, Christine
Milne, Gillian C.
Kuffová, Lucia
Forrester, John V.
author_facet Liu, Yi-Hsia
Mölzer, Christine
Milne, Gillian C.
Kuffová, Lucia
Forrester, John V.
author_sort Liu, Yi-Hsia
collection PubMed
description Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.
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spelling pubmed-62991222018-12-21 Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model Liu, Yi-Hsia Mölzer, Christine Milne, Gillian C. Kuffová, Lucia Forrester, John V. Data Brief Medicine and Dentistry Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD. Elsevier 2018-12-06 /pmc/articles/PMC6299122/ /pubmed/30581918 http://dx.doi.org/10.1016/j.dib.2018.12.007 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Medicine and Dentistry
Liu, Yi-Hsia
Mölzer, Christine
Milne, Gillian C.
Kuffová, Lucia
Forrester, John V.
Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title_full Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title_fullStr Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title_full_unstemmed Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title_short Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model
title_sort transmission electron microscopy data on drusen-like deposits in the retinal degeneration stg-irbp: hel mouse model
topic Medicine and Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299122/
https://www.ncbi.nlm.nih.gov/pubmed/30581918
http://dx.doi.org/10.1016/j.dib.2018.12.007
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