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Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has...

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Detalles Bibliográficos
Autores principales:	Jia, Qingzhu, Wu, Wei, Wang, Yuqi, Alexander, Peter B., Sun, Chengdu, Gong, Zhihua, Cheng, Jia-Nan, Sun, Huaibo, Guan, Yanfang, Xia, Xuefeng, Yang, Ling, Yi, Xin, Wan, Yisong Y., Wang, Haidong, He, Ji, Futreal, P. Andrew, Li, Qi-Jing, Zhu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299138/ https://www.ncbi.nlm.nih.gov/pubmed/30560866 http://dx.doi.org/10.1038/s41467-018-07767-w

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