Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

TRIM5 is a RING domain E3 ubiquitin ligase with potent antiretroviral function. TRIM5 assembles into a hexagonal lattice on retroviral capsids, causing envelopment of the infectious core. Concomitantly, TRIM5 initiates innate immune signaling and orchestrates disassembly of the viral particle, yet h...

Descripción completa

Detalles Bibliográficos
Autores principales: Fletcher, Adam J., Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J., James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299210/
https://www.ncbi.nlm.nih.gov/pubmed/30503508
http://dx.doi.org/10.1016/j.chom.2018.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299210/
https://www.ncbi.nlm.nih.gov/pubmed/30503508
http://dx.doi.org/10.1016/j.chom.2018.10.007

Ejemplares similares