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Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

TRIM5 is a RING domain E3 ubiquitin ligase with potent antiretroviral function. TRIM5 assembles into a hexagonal lattice on retroviral capsids, causing envelopment of the infectious core. Concomitantly, TRIM5 initiates innate immune signaling and orchestrates disassembly of the viral particle, yet h...

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Detalles Bibliográficos
Autores principales:	Fletcher, Adam J., Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J., James, Leo C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299210/ https://www.ncbi.nlm.nih.gov/pubmed/30503508 http://dx.doi.org/10.1016/j.chom.2018.10.007

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