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Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

Daptomycin, a calcium-dependent lipopeptide antibiotic whose full mode of action is still not entirely understood, has become a standard-of-care agent for treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Daptomycin-resistant (DAP-R) S. aureus mutants emerge during therapy, fea...

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Detalles Bibliográficos
Autores principales:	Ernst, Christoph M., Slavetinsky, Christoph J., Kuhn, Sebastian, Hauser, Janna N., Nega, Mulugeta, Mishra, Nagendra N., Gekeler, Cordula, Bayer, Arnold S., Peschel, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299216/ https://www.ncbi.nlm.nih.gov/pubmed/30563904 http://dx.doi.org/10.1128/mBio.01659-18

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