Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report

The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respe...

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Autores principales: Roozen, Geert, Revet, Ingrid, Raymakers, Reinier, Kemperman, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299261/
https://www.ncbi.nlm.nih.gov/pubmed/30027777
http://dx.doi.org/10.1177/0004563218793166
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author Roozen, Geert
Revet, Ingrid
Raymakers, Reinier
Kemperman, Hans
author_facet Roozen, Geert
Revet, Ingrid
Raymakers, Reinier
Kemperman, Hans
author_sort Roozen, Geert
collection PubMed
description The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking.
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spelling pubmed-62992612018-12-26 Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report Roozen, Geert Revet, Ingrid Raymakers, Reinier Kemperman, Hans Ann Clin Biochem Case Report The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking. SAGE Publications 2018-08-09 2019-01 /pmc/articles/PMC6299261/ /pubmed/30027777 http://dx.doi.org/10.1177/0004563218793166 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Roozen, Geert
Revet, Ingrid
Raymakers, Reinier
Kemperman, Hans
Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title_full Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title_fullStr Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title_full_unstemmed Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title_short Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
title_sort falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299261/
https://www.ncbi.nlm.nih.gov/pubmed/30027777
http://dx.doi.org/10.1177/0004563218793166
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