Cargando…

Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity

Objective: Blood flow restriction training (BFRT) has been proposed to induce muscle hypertrophy, but its safety remains controversial as it may increase mean arterial pressure (MAP) due to muscle metaboreflex activation. However, BFR training also causes metabolite accumulation that may desensitize...

Descripción completa

Detalles Bibliográficos
Autores principales: Crisafulli, Antonio, de Farias, Rafael Riera, Farinatti, Paulo, Lopes, Karynne Grutter, Milia, Raffaele, Sainas, Gianmarco, Pinna, Virginia, Palazzolo, Girolamo, Doneddu, Azzurra, Magnani, Sara, Mulliri, Gabriele, Roberto, Silvana, Oliveira, Ricardo Brandão
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299290/
https://www.ncbi.nlm.nih.gov/pubmed/30618781
http://dx.doi.org/10.3389/fphys.2018.01736
_version_ 1783381450541760512
author Crisafulli, Antonio
de Farias, Rafael Riera
Farinatti, Paulo
Lopes, Karynne Grutter
Milia, Raffaele
Sainas, Gianmarco
Pinna, Virginia
Palazzolo, Girolamo
Doneddu, Azzurra
Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Oliveira, Ricardo Brandão
author_facet Crisafulli, Antonio
de Farias, Rafael Riera
Farinatti, Paulo
Lopes, Karynne Grutter
Milia, Raffaele
Sainas, Gianmarco
Pinna, Virginia
Palazzolo, Girolamo
Doneddu, Azzurra
Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Oliveira, Ricardo Brandão
author_sort Crisafulli, Antonio
collection PubMed
description Objective: Blood flow restriction training (BFRT) has been proposed to induce muscle hypertrophy, but its safety remains controversial as it may increase mean arterial pressure (MAP) due to muscle metaboreflex activation. However, BFR training also causes metabolite accumulation that may desensitize type III and IV nerve endings, which trigger muscle metaboreflex. Then, we hypothesized that a period of BFR training would result in blunted hemodynamic activation during muscle metaboreflex. Methods: 17 young healthy males aged 18–25 yrs enrolled in this study. Hemodynamic responses during muscle metaboreflex were assessed by means of postexercise muscle ischemia (PEMI) at baseline (T0) and after 1 month (T1) of dynamic BFRT. BFRT consisted of 3-min rhythmic handgrip exercise applied 3 days/week (30 contractions per minute at 30% of maximum voluntary contraction) in the dominant arm. On the first week, the occlusion was set at 75% of resting systolic blood pressure (always obtained after 3 min of resting) and increased 25% every week, until reaching 150% of resting systolic pressure at week four. Hemodynamic measurements were assessed by means of impedance cardiography. Results: BFRT reduced MAP during handgrip exercise (T1: 96.3 ± 8.3 mmHg vs. T0: 102.0 ± 9.53 mmHg, p = 0.012). However, no significant time effect was detected for MAP during the metaboreflex activation (P > 0.05). Additionally, none of the observed hemodynamic outcomes, including systemic vascular resistance (SVR), showed significant difference between T0 and T1 during the metaboreflex activation (P > 0.05). Conclusion: BFRT reduced blood pressure during handgrip exercise, thereby suggesting a potential hypotensive effect of this modality of training. However, MAP reduction during handgrip seemed not to be provoked by lowered metaboreflex activity.
format Online
Article
Text
id pubmed-6299290
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-62992902019-01-07 Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity Crisafulli, Antonio de Farias, Rafael Riera Farinatti, Paulo Lopes, Karynne Grutter Milia, Raffaele Sainas, Gianmarco Pinna, Virginia Palazzolo, Girolamo Doneddu, Azzurra Magnani, Sara Mulliri, Gabriele Roberto, Silvana Oliveira, Ricardo Brandão Front Physiol Physiology Objective: Blood flow restriction training (BFRT) has been proposed to induce muscle hypertrophy, but its safety remains controversial as it may increase mean arterial pressure (MAP) due to muscle metaboreflex activation. However, BFR training also causes metabolite accumulation that may desensitize type III and IV nerve endings, which trigger muscle metaboreflex. Then, we hypothesized that a period of BFR training would result in blunted hemodynamic activation during muscle metaboreflex. Methods: 17 young healthy males aged 18–25 yrs enrolled in this study. Hemodynamic responses during muscle metaboreflex were assessed by means of postexercise muscle ischemia (PEMI) at baseline (T0) and after 1 month (T1) of dynamic BFRT. BFRT consisted of 3-min rhythmic handgrip exercise applied 3 days/week (30 contractions per minute at 30% of maximum voluntary contraction) in the dominant arm. On the first week, the occlusion was set at 75% of resting systolic blood pressure (always obtained after 3 min of resting) and increased 25% every week, until reaching 150% of resting systolic pressure at week four. Hemodynamic measurements were assessed by means of impedance cardiography. Results: BFRT reduced MAP during handgrip exercise (T1: 96.3 ± 8.3 mmHg vs. T0: 102.0 ± 9.53 mmHg, p = 0.012). However, no significant time effect was detected for MAP during the metaboreflex activation (P > 0.05). Additionally, none of the observed hemodynamic outcomes, including systemic vascular resistance (SVR), showed significant difference between T0 and T1 during the metaboreflex activation (P > 0.05). Conclusion: BFRT reduced blood pressure during handgrip exercise, thereby suggesting a potential hypotensive effect of this modality of training. However, MAP reduction during handgrip seemed not to be provoked by lowered metaboreflex activity. Frontiers Media S.A. 2018-12-04 /pmc/articles/PMC6299290/ /pubmed/30618781 http://dx.doi.org/10.3389/fphys.2018.01736 Text en Copyright © 2018 Crisafulli, de Farias, Farinatti, Lopes, Milia, Sainas, Pinna, Palazzolo, Doneddu, Magnani, Mulliri, Roberto and Oliveira. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Crisafulli, Antonio
de Farias, Rafael Riera
Farinatti, Paulo
Lopes, Karynne Grutter
Milia, Raffaele
Sainas, Gianmarco
Pinna, Virginia
Palazzolo, Girolamo
Doneddu, Azzurra
Magnani, Sara
Mulliri, Gabriele
Roberto, Silvana
Oliveira, Ricardo Brandão
Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title_full Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title_fullStr Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title_full_unstemmed Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title_short Blood Flow Restriction Training Reduces Blood Pressure During Exercise Without Affecting Metaboreflex Activity
title_sort blood flow restriction training reduces blood pressure during exercise without affecting metaboreflex activity
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299290/
https://www.ncbi.nlm.nih.gov/pubmed/30618781
http://dx.doi.org/10.3389/fphys.2018.01736
work_keys_str_mv AT crisafulliantonio bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT defariasrafaelriera bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT farinattipaulo bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT lopeskarynnegrutter bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT miliaraffaele bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT sainasgianmarco bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT pinnavirginia bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT palazzologirolamo bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT donedduazzurra bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT magnanisara bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT mullirigabriele bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT robertosilvana bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity
AT oliveiraricardobrandao bloodflowrestrictiontrainingreducesbloodpressureduringexercisewithoutaffectingmetaboreflexactivity