Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib

This study is an unbiased genomic screen to obtain functional targets for increased effectiveness of dasatinib in pancreatic cancer. Dasatinib, a multi-targeted tyrosine kinase inhibitor, is used in clinical trials for treatment of pancreatic cancer; however, intrinsic and acquired resistance often...

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Detalles Bibliográficos
Autores principales: Chien, Wenwen, Sudo, Makoto, Ding, Ling-Wen, Sun, Qiao-Yang, Wuensche, Peer, Lee, Kian Leong, Hattori, Norimichi, Garg, Manoj, Xu, Liang, Zheng, Yun, Gery, Sigal, Wongphayak, Sarawut, Yang, Henry, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Mori, Seiichi, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299388/
https://www.ncbi.nlm.nih.gov/pubmed/30588262
http://dx.doi.org/10.7150/jca.25138

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