Cargando…
Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics
The high mobility group box 1 gene (HMGB1) plays a prominent role in cancer progression, angiogenesis, invasion, and metastasis. This study explored the effect of HMGB1 polymorphisms on clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 1293 participants (431 patients...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299401/ https://www.ncbi.nlm.nih.gov/pubmed/30588197 http://dx.doi.org/10.7150/ijms.27901 |
_version_ | 1783381475003990016 |
---|---|
author | Hung, Sheng-Chun Wang, Shian-Shiang Li, Jian-Ri Chen, Chuan-Shu Yang, Chun-Kuang Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Ho, Hao-Chung Yang, Shun-Fa |
author_facet | Hung, Sheng-Chun Wang, Shian-Shiang Li, Jian-Ri Chen, Chuan-Shu Yang, Chun-Kuang Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Ho, Hao-Chung Yang, Shun-Fa |
author_sort | Hung, Sheng-Chun |
collection | PubMed |
description | The high mobility group box 1 gene (HMGB1) plays a prominent role in cancer progression, angiogenesis, invasion, and metastasis. This study explored the effect of HMGB1 polymorphisms on clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 1293 participants (431 patients with UCC and 862 healthy controls) were recruited. Four single-nucleotide polymorphisms (SNPs) of HMGB1 (rs1412125, rs1360485, rs1045411, and rs2249825) were assessed using TaqMan real-time polymerase chain reaction assay. The results indicated that individuals carrying at least one T allele at rs1045411 had a lower risk of UCC than those with the wild-type allele [adjusted odds ratio = 0.722, 95% confidence interval (CI) = 0.565-0.924]. Furthermore, female patients with UCC carrying at least one T allele at rs1045411 were at a lower invasive tumor stage than those with the wild-type allele [odds ratio (OR) = 0.396, 95% CI = 0.169-0.929], similar to nonsmoking patients (OR = 0.607, 95% CI = 0.374-0.985). In conclusion, this is the first report on correlation between HMGB1 polymorphisms and UCC risk. Individuals carrying at least one T allele at rs1045411 are associated with a lower risk of UCC and a less invasive disease in women and nonsmokers. |
format | Online Article Text |
id | pubmed-6299401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-62994012018-12-26 Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics Hung, Sheng-Chun Wang, Shian-Shiang Li, Jian-Ri Chen, Chuan-Shu Yang, Chun-Kuang Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Ho, Hao-Chung Yang, Shun-Fa Int J Med Sci Research Paper The high mobility group box 1 gene (HMGB1) plays a prominent role in cancer progression, angiogenesis, invasion, and metastasis. This study explored the effect of HMGB1 polymorphisms on clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 1293 participants (431 patients with UCC and 862 healthy controls) were recruited. Four single-nucleotide polymorphisms (SNPs) of HMGB1 (rs1412125, rs1360485, rs1045411, and rs2249825) were assessed using TaqMan real-time polymerase chain reaction assay. The results indicated that individuals carrying at least one T allele at rs1045411 had a lower risk of UCC than those with the wild-type allele [adjusted odds ratio = 0.722, 95% confidence interval (CI) = 0.565-0.924]. Furthermore, female patients with UCC carrying at least one T allele at rs1045411 were at a lower invasive tumor stage than those with the wild-type allele [odds ratio (OR) = 0.396, 95% CI = 0.169-0.929], similar to nonsmoking patients (OR = 0.607, 95% CI = 0.374-0.985). In conclusion, this is the first report on correlation between HMGB1 polymorphisms and UCC risk. Individuals carrying at least one T allele at rs1045411 are associated with a lower risk of UCC and a less invasive disease in women and nonsmokers. Ivyspring International Publisher 2018-11-22 /pmc/articles/PMC6299401/ /pubmed/30588197 http://dx.doi.org/10.7150/ijms.27901 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Hung, Sheng-Chun Wang, Shian-Shiang Li, Jian-Ri Chen, Chuan-Shu Yang, Chun-Kuang Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Ho, Hao-Chung Yang, Shun-Fa Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title | Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title_full | Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title_fullStr | Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title_full_unstemmed | Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title_short | Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics |
title_sort | effect of hmgb1 polymorphisms on urothelial cell carcinoma susceptibility and clinicopathological characteristics |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299401/ https://www.ncbi.nlm.nih.gov/pubmed/30588197 http://dx.doi.org/10.7150/ijms.27901 |
work_keys_str_mv | AT hungshengchun effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT wangshianshiang effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT lijianri effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT chenchuanshu effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT yangchunkuang effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT chiukunyuan effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT chengchenli effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT ouyenchuan effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT hohaochung effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics AT yangshunfa effectofhmgb1polymorphismsonurothelialcellcarcinomasusceptibilityandclinicopathologicalcharacteristics |