Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery

Extra domain B of fibronectin (FN-EDB) is upregulated in the extracellular matrix during tissue remodeling and has been postulated as a potential biomarker for atherosclerosis, yet no systematic test for FN-EDB in plaques has been reported. We hypothesized that FN-EDB expression would intensify in a...

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Detalles Bibliográficos
Autores principales: Yu, Mikyung, Ortega, Carleena A., Si, Kevin, Molinaro, Roberto, Schoen, Frederick J., Leitao, Renata F. C., Xu, Xiaoding, Mahmoudi, Morteza, Ahn, Suyeon, Liu, Jerry, Saw, Phei Er, Lee, In-Hyun, Brayner, Mirna M. B., Lotfi, Azita, Shi, Jinjun, Libby, Peter, Jon, Sangyong, Farokhzad, Omid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299428/
https://www.ncbi.nlm.nih.gov/pubmed/30613278
http://dx.doi.org/10.7150/thno.24365

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