Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story

The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as...

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Autores principales: Corti, Alessandro, Belcastro, Eugenia, Pompella, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299431/
https://www.ncbi.nlm.nih.gov/pubmed/30613280
http://dx.doi.org/10.7150/thno.29864
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author Corti, Alessandro
Belcastro, Eugenia
Pompella, Alfonso
author_facet Corti, Alessandro
Belcastro, Eugenia
Pompella, Alfonso
author_sort Corti, Alessandro
collection PubMed
description The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant expression of membrane gamma-glutamyltransferase activity, the resistance of cancer cells to oxidative injury and other known biomarkers.
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spelling pubmed-62994312019-01-04 Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story Corti, Alessandro Belcastro, Eugenia Pompella, Alfonso Theranostics Editorial The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant expression of membrane gamma-glutamyltransferase activity, the resistance of cancer cells to oxidative injury and other known biomarkers. Ivyspring International Publisher 2018-11-15 /pmc/articles/PMC6299431/ /pubmed/30613280 http://dx.doi.org/10.7150/thno.29864 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Editorial
Corti, Alessandro
Belcastro, Eugenia
Pompella, Alfonso
Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title_full Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title_fullStr Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title_full_unstemmed Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title_short Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
title_sort antitumoral effects of pharmacological ascorbate on gastric cancer cells: glut1 expression may not tell the whole story
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299431/
https://www.ncbi.nlm.nih.gov/pubmed/30613280
http://dx.doi.org/10.7150/thno.29864
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