Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) trimer evades antibody recognition by adopting a closed prefusion conformation. Here, we show that two conserved tyrosines (Y173, Y177) within the second variable (V2) loop of the gp120 Env glycoprotein are key regulators of the closed,...

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Detalles Bibliográficos
Autores principales: Guzzo, Christina, Zhang, Peng, Liu, Qingbo, Kwon, Alice L., Uddin, Ferzan, Wells, Alexandra I., Schmeisser, Hana, Cimbro, Raffaello, Huang, Jinghe, Doria-Rose, Nicole, Schmidt, Stephen D., Dolan, Michael A., Connors, Mark, Mascola, John R., Lusso, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299476/
https://www.ncbi.nlm.nih.gov/pubmed/30538178
http://dx.doi.org/10.1128/mBio.00955-18

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