Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epigenetic alteration underlying cancer pathogenesis. METHODS: We evaluated AZIN...

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Detalles Bibliográficos
Autores principales: Okugawa, Yoshinaga, Toiyama, Yuji, Shigeyasu, Kunitoshi, Yamamoto, Akira, Shigemori, Tsunehiko, Yin, Chengzeng, Ichikawa, Takashi, Yasuda, Hiromi, Fujikawa, Hiroyuki, Yoshiyama, Shigeyuki, Hiro, Junichiro, Ohi, Masaki, Araki, Toshimitsu, Kusunoki, Masato, Goel, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299520/
https://www.ncbi.nlm.nih.gov/pubmed/30563560
http://dx.doi.org/10.1186/s12967-018-1740-z

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