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The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection

BACKGROUND: Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections. METHODS: This study examined the relationships between HLA-DQB1 alleles and HBV infection suscept...

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Autores principales: Ou, Guojin, Xu, Haixia, Yu, Hao, Liu, Xiao, Yang, Liu, Ji, Xin, Wang, Jue, Liu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299522/
https://www.ncbi.nlm.nih.gov/pubmed/30563535
http://dx.doi.org/10.1186/s12967-018-1716-z
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author Ou, Guojin
Xu, Haixia
Yu, Hao
Liu, Xiao
Yang, Liu
Ji, Xin
Wang, Jue
Liu, Zhong
author_facet Ou, Guojin
Xu, Haixia
Yu, Hao
Liu, Xiao
Yang, Liu
Ji, Xin
Wang, Jue
Liu, Zhong
author_sort Ou, Guojin
collection PubMed
description BACKGROUND: Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections. METHODS: This study examined the relationships between HLA-DQB1 alleles and HBV infection susceptibility among 256 HBV carriers and 433 healthy controls. Venous blood samples were subjected to DQB1 high-resolution typing and testing for interferon-gamma, interleukin-4 (IL-4), interleukin-10, and DQB1 mRNA expression. A meta-analysis was also performed using relevant case–control studies that evaluated the associations of HLA-DQB1 alleles with HBV infection and clearance. RESULTS: We found that HLA-DQB1*06:03 protected against HBV infection. Levels of IFN-γ and IL-4 were significantly elevated in HBV cases with HLA-DQB1*06:05 (vs. HLA-DQB1*05:03), and the HBV group had higher DQB1 mRNA expression than the healthy control group with HLA-DQB1*05:03 and HLA-DQB1*06:02. The meta-analysis revealed that HLA-DQB1*04:01, HLA-DQB1*05:02, HLA-DQB1*05:03, and HLA-DQB1*06:01 were risk factors for HBV infection susceptibility, while HLA-DQB1*05:01, HLA-DQB1*06:03, and HLA-DQB1*06:04 protected against HBV infection. Spontaneous HBV clearance was associated withHLA-DQB1*06:04, while chronic HBV infection was associated with HLA-DQB1*02:01 and HLA-DQB1*05:02. CONCLUSION: DBQ1 typing can be used to identify patients who have elevated risks of HBV infection (i.e., patients with HLA-DQB1*04:01, HLA-DQB1*05:02, HLA-DQB1*05:03, and HLA-DQB1*06:01) or elevated risks of chronic HBV infection (i.e., patients with HLA-DQB1*02:01 and HLA-DQB1*05:02). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-018-1716-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-62995222018-12-20 The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection Ou, Guojin Xu, Haixia Yu, Hao Liu, Xiao Yang, Liu Ji, Xin Wang, Jue Liu, Zhong J Transl Med Research BACKGROUND: Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections. METHODS: This study examined the relationships between HLA-DQB1 alleles and HBV infection susceptibility among 256 HBV carriers and 433 healthy controls. Venous blood samples were subjected to DQB1 high-resolution typing and testing for interferon-gamma, interleukin-4 (IL-4), interleukin-10, and DQB1 mRNA expression. A meta-analysis was also performed using relevant case–control studies that evaluated the associations of HLA-DQB1 alleles with HBV infection and clearance. RESULTS: We found that HLA-DQB1*06:03 protected against HBV infection. Levels of IFN-γ and IL-4 were significantly elevated in HBV cases with HLA-DQB1*06:05 (vs. HLA-DQB1*05:03), and the HBV group had higher DQB1 mRNA expression than the healthy control group with HLA-DQB1*05:03 and HLA-DQB1*06:02. The meta-analysis revealed that HLA-DQB1*04:01, HLA-DQB1*05:02, HLA-DQB1*05:03, and HLA-DQB1*06:01 were risk factors for HBV infection susceptibility, while HLA-DQB1*05:01, HLA-DQB1*06:03, and HLA-DQB1*06:04 protected against HBV infection. Spontaneous HBV clearance was associated withHLA-DQB1*06:04, while chronic HBV infection was associated with HLA-DQB1*02:01 and HLA-DQB1*05:02. CONCLUSION: DBQ1 typing can be used to identify patients who have elevated risks of HBV infection (i.e., patients with HLA-DQB1*04:01, HLA-DQB1*05:02, HLA-DQB1*05:03, and HLA-DQB1*06:01) or elevated risks of chronic HBV infection (i.e., patients with HLA-DQB1*02:01 and HLA-DQB1*05:02). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-018-1716-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-18 /pmc/articles/PMC6299522/ /pubmed/30563535 http://dx.doi.org/10.1186/s12967-018-1716-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ou, Guojin
Xu, Haixia
Yu, Hao
Liu, Xiao
Yang, Liu
Ji, Xin
Wang, Jue
Liu, Zhong
The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title_full The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title_fullStr The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title_full_unstemmed The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title_short The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection
title_sort roles of hla-dqb1 gene polymorphisms in hepatitis b virus infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299522/
https://www.ncbi.nlm.nih.gov/pubmed/30563535
http://dx.doi.org/10.1186/s12967-018-1716-z
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