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Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

BACKGROUND: Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns. In contrast, uniform flow (UF), normal endothelium, and healthy vessel walls co-exist within straight vessels. In...

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Detalles Bibliográficos
Autores principales: Harding, Ian C., Mitra, Ronodeep, Mensah, Solomon A., Herman, Ira M., Ebong, Eno E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299559/
https://www.ncbi.nlm.nih.gov/pubmed/30563532
http://dx.doi.org/10.1186/s12967-018-1721-2