Cargando…

Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder

BACKGROUND: Clinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known to increase the risk of developing a number of life threatening diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jingxu, Chen, Hongmei, Feng, Junhui, Zhang, Ligang, Li, Juyan, Li, Ran, Wang, Shaoli, Wilson, Ian, Jones, Alison, Tan, Yunlong, Yang, Fude, Huang, Xu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299580/
https://www.ncbi.nlm.nih.gov/pubmed/30563493
http://dx.doi.org/10.1186/s12888-018-1952-z
_version_ 1783381515181228032
author Chen, Jingxu
Chen, Hongmei
Feng, Junhui
Zhang, Ligang
Li, Juyan
Li, Ran
Wang, Shaoli
Wilson, Ian
Jones, Alison
Tan, Yunlong
Yang, Fude
Huang, Xu-Feng
author_facet Chen, Jingxu
Chen, Hongmei
Feng, Junhui
Zhang, Ligang
Li, Juyan
Li, Ran
Wang, Shaoli
Wilson, Ian
Jones, Alison
Tan, Yunlong
Yang, Fude
Huang, Xu-Feng
author_sort Chen, Jingxu
collection PubMed
description BACKGROUND: Clinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known to increase the risk of developing a number of life threatening diseases including coronary heart disease, hypertension, and type 2 diabetes. This study investigated the association between hyperuricemia and metabolic syndrome and its components in individuals suffering from bipolar disorders. METHODS: This study recruited 318 inpatients suffering from bipolar disorders from Beijing Hui-Long-Guan Hospital in China and 160 healthy subjects from the same region as the controls. We used National Cholesterol Education Program Adult Treatment Panel III Adapted criteria (NCEP ATP-III A) for the diagnosis of metabolic syndrome. Hyperuricemia was determined as serum uric acid level above 420 μmol/L in men and 360 μmol/L in women (N Engl J Med 359(17):1811–1821, 2008). RESULTS: Among 318 bipolar patients, there was higher prevalence of metabolic syndrome (42.5%) and hyperuricemia (27.7%) than healthy controls (21.9 and 11.9%). Bipolar patients with metabolic syndrome had increased prevalence of hyperuricemia (OR = 3.0, CI95 [1.7–5.4]). Hypertriglyceridemia and larger waist circumference (WC) were associated with hyperunicemia (OR = 1.8, CI95 [1.1–3.1], OR = 1.9, CI95 [1.1–3.4]). Hyperuricemia was associated with metabolic syndrome in bipolar patients (p < 0.001) and especially with hypertriglyceridemia (OR = 1.9, CI95 [1.1–3.1] and increased WC (OR = 2.1 [1.2–4.0]). Bipolar patients over 50 years of age and hyperuricemia were highly prone to develop metabolic syndrome (OR = 14.0, CI95 [5.0–39.0]). CONCLUSIONS: Hyperuricemia was highly associated with development of metabolic disorder particularly for aged patients suffering from bipolar disorders. Early prevention of hyperuricemia and metabolic syndrome may lead better life for bipolar patients when they get older.
format Online
Article
Text
id pubmed-6299580
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-62995802018-12-20 Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder Chen, Jingxu Chen, Hongmei Feng, Junhui Zhang, Ligang Li, Juyan Li, Ran Wang, Shaoli Wilson, Ian Jones, Alison Tan, Yunlong Yang, Fude Huang, Xu-Feng BMC Psychiatry Research Article BACKGROUND: Clinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known to increase the risk of developing a number of life threatening diseases including coronary heart disease, hypertension, and type 2 diabetes. This study investigated the association between hyperuricemia and metabolic syndrome and its components in individuals suffering from bipolar disorders. METHODS: This study recruited 318 inpatients suffering from bipolar disorders from Beijing Hui-Long-Guan Hospital in China and 160 healthy subjects from the same region as the controls. We used National Cholesterol Education Program Adult Treatment Panel III Adapted criteria (NCEP ATP-III A) for the diagnosis of metabolic syndrome. Hyperuricemia was determined as serum uric acid level above 420 μmol/L in men and 360 μmol/L in women (N Engl J Med 359(17):1811–1821, 2008). RESULTS: Among 318 bipolar patients, there was higher prevalence of metabolic syndrome (42.5%) and hyperuricemia (27.7%) than healthy controls (21.9 and 11.9%). Bipolar patients with metabolic syndrome had increased prevalence of hyperuricemia (OR = 3.0, CI95 [1.7–5.4]). Hypertriglyceridemia and larger waist circumference (WC) were associated with hyperunicemia (OR = 1.8, CI95 [1.1–3.1], OR = 1.9, CI95 [1.1–3.4]). Hyperuricemia was associated with metabolic syndrome in bipolar patients (p < 0.001) and especially with hypertriglyceridemia (OR = 1.9, CI95 [1.1–3.1] and increased WC (OR = 2.1 [1.2–4.0]). Bipolar patients over 50 years of age and hyperuricemia were highly prone to develop metabolic syndrome (OR = 14.0, CI95 [5.0–39.0]). CONCLUSIONS: Hyperuricemia was highly associated with development of metabolic disorder particularly for aged patients suffering from bipolar disorders. Early prevention of hyperuricemia and metabolic syndrome may lead better life for bipolar patients when they get older. BioMed Central 2018-12-18 /pmc/articles/PMC6299580/ /pubmed/30563493 http://dx.doi.org/10.1186/s12888-018-1952-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Jingxu
Chen, Hongmei
Feng, Junhui
Zhang, Ligang
Li, Juyan
Li, Ran
Wang, Shaoli
Wilson, Ian
Jones, Alison
Tan, Yunlong
Yang, Fude
Huang, Xu-Feng
Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title_full Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title_fullStr Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title_full_unstemmed Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title_short Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
title_sort association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299580/
https://www.ncbi.nlm.nih.gov/pubmed/30563493
http://dx.doi.org/10.1186/s12888-018-1952-z
work_keys_str_mv AT chenjingxu associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT chenhongmei associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT fengjunhui associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT zhangligang associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT lijuyan associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT liran associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT wangshaoli associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT wilsonian associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT jonesalison associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT tanyunlong associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT yangfude associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder
AT huangxufeng associationbetweenhyperuricemiaandmetabolicsyndromeinpatientssufferingfrombipolardisorder