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Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK

BACKGROUND: Acyl-coenzymeA: cholesterol acyltransferase (ACAT) 1, a key enzyme converting excess free cholesterol to cholesterol esters, has been demonstrated to be associated with the pathogenesis of Alzheimer disease (AD). However, the mechanism underlying the protective role of ACAT1 blockage in...

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Detalles Bibliográficos
Autores principales:	Chen, Ying, Zhu, Lu, Ji, Lei, Yang, Ying, Lu, Lu, Wang, Xiaodong, Zhou, Guomin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299791/ https://www.ncbi.nlm.nih.gov/pubmed/30541014 http://dx.doi.org/10.12659/MSM.912862

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