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Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells

Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus s...

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Autor principal: Rajeshkumar, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Scientific Research and Technology, Egypt 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299896/
https://www.ncbi.nlm.nih.gov/pubmed/30647615
http://dx.doi.org/10.1016/j.jgeb.2016.05.007
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author Rajeshkumar, S.
author_facet Rajeshkumar, S.
author_sort Rajeshkumar, S.
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description Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus sp. The nanoparticle synthesis started at 2 h of incubation time was identified by the formation of ruby red in the reaction mixture and SPR band centered at 545 nm. XRD shows that the strong four intense peaks indicate crystalline nature of nanoparticles. Morphology of nanoparticles analyzed by TEM shows that they are mostly spherical in shape with size ranging from 6 to 13 nm. EDX supports the presence of gold in the synthesized nanoparticles. FTIR reveals the active functional groups in the culture supernatant interaction with gold nanoparticles. As a result synthesized stable gold nanoparticles show more significant anticancer activity against HepG2 and A549 cells at 100 μg concentration of nanoparticles. This synthesis approach is simple, large scaled up a new door for development of targeted anticancer activity using gold nanoparticles and is novel in biomedical applications.
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spelling pubmed-62998962019-01-15 Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells Rajeshkumar, S. J Genet Eng Biotechnol Original Article Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus sp. The nanoparticle synthesis started at 2 h of incubation time was identified by the formation of ruby red in the reaction mixture and SPR band centered at 545 nm. XRD shows that the strong four intense peaks indicate crystalline nature of nanoparticles. Morphology of nanoparticles analyzed by TEM shows that they are mostly spherical in shape with size ranging from 6 to 13 nm. EDX supports the presence of gold in the synthesized nanoparticles. FTIR reveals the active functional groups in the culture supernatant interaction with gold nanoparticles. As a result synthesized stable gold nanoparticles show more significant anticancer activity against HepG2 and A549 cells at 100 μg concentration of nanoparticles. This synthesis approach is simple, large scaled up a new door for development of targeted anticancer activity using gold nanoparticles and is novel in biomedical applications. Academy of Scientific Research and Technology, Egypt 2016-06 2016-06-09 /pmc/articles/PMC6299896/ /pubmed/30647615 http://dx.doi.org/10.1016/j.jgeb.2016.05.007 Text en © 2016 Production and hosting by Elsevier B.V. on behalf of Academy of Scientific Research & Technology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rajeshkumar, S.
Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title_full Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title_fullStr Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title_full_unstemmed Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title_short Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
title_sort anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299896/
https://www.ncbi.nlm.nih.gov/pubmed/30647615
http://dx.doi.org/10.1016/j.jgeb.2016.05.007
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