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Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells
Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academy of Scientific Research and Technology, Egypt
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299896/ https://www.ncbi.nlm.nih.gov/pubmed/30647615 http://dx.doi.org/10.1016/j.jgeb.2016.05.007 |
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author | Rajeshkumar, S. |
author_facet | Rajeshkumar, S. |
author_sort | Rajeshkumar, S. |
collection | PubMed |
description | Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus sp. The nanoparticle synthesis started at 2 h of incubation time was identified by the formation of ruby red in the reaction mixture and SPR band centered at 545 nm. XRD shows that the strong four intense peaks indicate crystalline nature of nanoparticles. Morphology of nanoparticles analyzed by TEM shows that they are mostly spherical in shape with size ranging from 6 to 13 nm. EDX supports the presence of gold in the synthesized nanoparticles. FTIR reveals the active functional groups in the culture supernatant interaction with gold nanoparticles. As a result synthesized stable gold nanoparticles show more significant anticancer activity against HepG2 and A549 cells at 100 μg concentration of nanoparticles. This synthesis approach is simple, large scaled up a new door for development of targeted anticancer activity using gold nanoparticles and is novel in biomedical applications. |
format | Online Article Text |
id | pubmed-6299896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Academy of Scientific Research and Technology, Egypt |
record_format | MEDLINE/PubMed |
spelling | pubmed-62998962019-01-15 Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells Rajeshkumar, S. J Genet Eng Biotechnol Original Article Gold nanoparticles have many applications in biomedical field. Improving delivery of anticancer agents to tumors using nanoparticles is one of the most promising research arenas in the field of nanotechnology. Eco-friendly gold nanoparticles synthesis was studied using marine bacteria Enterococcus sp. The nanoparticle synthesis started at 2 h of incubation time was identified by the formation of ruby red in the reaction mixture and SPR band centered at 545 nm. XRD shows that the strong four intense peaks indicate crystalline nature of nanoparticles. Morphology of nanoparticles analyzed by TEM shows that they are mostly spherical in shape with size ranging from 6 to 13 nm. EDX supports the presence of gold in the synthesized nanoparticles. FTIR reveals the active functional groups in the culture supernatant interaction with gold nanoparticles. As a result synthesized stable gold nanoparticles show more significant anticancer activity against HepG2 and A549 cells at 100 μg concentration of nanoparticles. This synthesis approach is simple, large scaled up a new door for development of targeted anticancer activity using gold nanoparticles and is novel in biomedical applications. Academy of Scientific Research and Technology, Egypt 2016-06 2016-06-09 /pmc/articles/PMC6299896/ /pubmed/30647615 http://dx.doi.org/10.1016/j.jgeb.2016.05.007 Text en © 2016 Production and hosting by Elsevier B.V. on behalf of Academy of Scientific Research & Technology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Rajeshkumar, S. Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title | Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title_full | Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title_fullStr | Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title_full_unstemmed | Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title_short | Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
title_sort | anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299896/ https://www.ncbi.nlm.nih.gov/pubmed/30647615 http://dx.doi.org/10.1016/j.jgeb.2016.05.007 |
work_keys_str_mv | AT rajeshkumars anticanceractivityofecofriendlygoldnanoparticlesagainstlungandlivercancercells |