Overcoming Target Driven Fratricide for T Cell Therapy

Chimeric Antigen Receptor (CAR) T cells expressing the fusion of the NKG2D protein with CD3ζ (NKG2D-CAR T Cells) acquire a specificity for stress-induced ligands expressed on hematological and solid cancers. However, these stress ligands are also transiently expressed by activated T cells implying t...

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Detalles Bibliográficos
Autores principales: Breman, Eytan, Demoulin, Benjamin, Agaugué, Sophie, Mauën, Sebastien, Michaux, Alexandre, Springuel, Lorraine, Houssa, Julien, Huberty, Fanny, Jacques-Hespel, Céline, Marchand, Céline, Marijsse, Jérôme, Nguyen, Thuy, Ramelot, Nancy, Violle, Benjamin, Daro, Dorothée, De Waele, Peter, Gilham, David E., Steenwinckel, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299907/
https://www.ncbi.nlm.nih.gov/pubmed/30619300
http://dx.doi.org/10.3389/fimmu.2018.02940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299907/
https://www.ncbi.nlm.nih.gov/pubmed/30619300
http://dx.doi.org/10.3389/fimmu.2018.02940

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