Cargando…
Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis
BACKGROUND: To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS: A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299957/ https://www.ncbi.nlm.nih.gov/pubmed/30567570 http://dx.doi.org/10.1186/s13075-018-1775-9 |
_version_ | 1783381594425262080 |
---|---|
author | Guillén-Del-Castillo, Alfredo Simeón-Aznar, Carmen Pilar Callejas-Moraga, Eduardo L. Tolosa-Vilella, Carles Alonso-Vila, Serafín Fonollosa-Pla, Vicente Selva-O’Callaghan, Albert |
author_facet | Guillén-Del-Castillo, Alfredo Simeón-Aznar, Carmen Pilar Callejas-Moraga, Eduardo L. Tolosa-Vilella, Carles Alonso-Vila, Serafín Fonollosa-Pla, Vicente Selva-O’Callaghan, Albert |
author_sort | Guillén-Del-Castillo, Alfredo |
collection | PubMed |
description | BACKGROUND: To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS: A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography were undergone within a 3-month period. Finally, 134 patients with at least eight NVC (200× magnification) images were selected for quantitative and qualitative examinations. RESULTS: Patients with interstitial lung disease presented lower median capillary density (4.86/mm vs 5.88/mm, p = 0.005) and higher median of neoangiogenesis (0.56/mm vs 0.31/mm, p = 0.005). A higher quantity of neoangiogenesis capillaries was found in patients with pulmonary arterial hypertension (0.70/mm vs 0.33/mm, p = 0.008). Multivariate linear regression analysis established a correlation between neoangiogenesis and decreased forced vital capacity (FVC) (p < 0.001): for each capillary with neoangiogenesis visualized on average per 1 mm, FVC was 7.3% reduced. In qualitative NVC, a late pattern as defined by Cutolo was also associated with lower FVC (p = 0.018). The number of giant capillaries was associated with reduced diffusion capacity of the lung for carbon monoxide (DLCO) (p = 0.016); for each giant capillary per 1 mm, DLCO was 11.8% diminished. CONCLUSIONS: A good correlation was observed between distinctive quantitative and qualitative NVC features with lung functional parameters such as FVC and DLCO. It is suggested that vasculopathy could play a role in SSc lung involvement. |
format | Online Article Text |
id | pubmed-6299957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62999572018-12-20 Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis Guillén-Del-Castillo, Alfredo Simeón-Aznar, Carmen Pilar Callejas-Moraga, Eduardo L. Tolosa-Vilella, Carles Alonso-Vila, Serafín Fonollosa-Pla, Vicente Selva-O’Callaghan, Albert Arthritis Res Ther Research Article BACKGROUND: To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS: A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography were undergone within a 3-month period. Finally, 134 patients with at least eight NVC (200× magnification) images were selected for quantitative and qualitative examinations. RESULTS: Patients with interstitial lung disease presented lower median capillary density (4.86/mm vs 5.88/mm, p = 0.005) and higher median of neoangiogenesis (0.56/mm vs 0.31/mm, p = 0.005). A higher quantity of neoangiogenesis capillaries was found in patients with pulmonary arterial hypertension (0.70/mm vs 0.33/mm, p = 0.008). Multivariate linear regression analysis established a correlation between neoangiogenesis and decreased forced vital capacity (FVC) (p < 0.001): for each capillary with neoangiogenesis visualized on average per 1 mm, FVC was 7.3% reduced. In qualitative NVC, a late pattern as defined by Cutolo was also associated with lower FVC (p = 0.018). The number of giant capillaries was associated with reduced diffusion capacity of the lung for carbon monoxide (DLCO) (p = 0.016); for each giant capillary per 1 mm, DLCO was 11.8% diminished. CONCLUSIONS: A good correlation was observed between distinctive quantitative and qualitative NVC features with lung functional parameters such as FVC and DLCO. It is suggested that vasculopathy could play a role in SSc lung involvement. BioMed Central 2018-12-19 2018 /pmc/articles/PMC6299957/ /pubmed/30567570 http://dx.doi.org/10.1186/s13075-018-1775-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Guillén-Del-Castillo, Alfredo Simeón-Aznar, Carmen Pilar Callejas-Moraga, Eduardo L. Tolosa-Vilella, Carles Alonso-Vila, Serafín Fonollosa-Pla, Vicente Selva-O’Callaghan, Albert Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title | Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title_full | Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title_fullStr | Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title_full_unstemmed | Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title_short | Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
title_sort | quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299957/ https://www.ncbi.nlm.nih.gov/pubmed/30567570 http://dx.doi.org/10.1186/s13075-018-1775-9 |
work_keys_str_mv | AT guillendelcastilloalfredo quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT simeonaznarcarmenpilar quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT callejasmoragaeduardol quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT tolosavilellacarles quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT alonsovilaserafin quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT fonollosaplavicente quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis AT selvaocallaghanalbert quantitativevideocapillaroscopycorrelateswithfunctionalrespiratoryparametersaclueforvasculopathyasapathogenicmechanismforlunginjuryinsystemicsclerosis |