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Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients

BACKGROUND: Excessive extracellular matrix (ECM) remodeling and a reactive stroma can affect T-cell infiltration and T-cell activity in the tumor and hereby influence response to immune checkpoint inhibitors (ICI). In the pursuit of finding biomarkers that predict treatment response, we evaluated th...

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Detalles Bibliográficos
Autores principales:	Jensen, Christina, Madsen, Daniel Hargbøl, Hansen, Morten, Schmidt, Henrik, Svane, Inge Marie, Karsdal, Morten Asser, Willumsen, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300009/ https://www.ncbi.nlm.nih.gov/pubmed/30567561 http://dx.doi.org/10.1186/s40425-018-0474-z

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