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Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil

BACKGROUND: Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently u...

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Autores principales: Corrêa, Angelita Silva de Miranda, Lamarão, Letícia Martins, Vieira, Priscilla Cristina Moura, de Castro, Renata Bezerra Hermes, de Almeida, Núbia Caroline Costa, de Castro, Jairo Augusto Américo, de Lima, Maria Salete Maciel, Palmeira, Mauricio Koury, Meireles, Ana Luiza Langanke Pedroso, Burbano, Rommel Rodríguez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300202/
https://www.ncbi.nlm.nih.gov/pubmed/30566494
http://dx.doi.org/10.1371/journal.pone.0208414
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author Corrêa, Angelita Silva de Miranda
Lamarão, Letícia Martins
Vieira, Priscilla Cristina Moura
de Castro, Renata Bezerra Hermes
de Almeida, Núbia Caroline Costa
de Castro, Jairo Augusto Américo
de Lima, Maria Salete Maciel
Palmeira, Mauricio Koury
Meireles, Ana Luiza Langanke Pedroso
Burbano, Rommel Rodríguez
author_facet Corrêa, Angelita Silva de Miranda
Lamarão, Letícia Martins
Vieira, Priscilla Cristina Moura
de Castro, Renata Bezerra Hermes
de Almeida, Núbia Caroline Costa
de Castro, Jairo Augusto Américo
de Lima, Maria Salete Maciel
Palmeira, Mauricio Koury
Meireles, Ana Luiza Langanke Pedroso
Burbano, Rommel Rodríguez
author_sort Corrêa, Angelita Silva de Miranda
collection PubMed
description BACKGROUND: Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomitant with serological tests (HBsAg and anti-HBc). This study aims to evaluate the prevalence and the incidence of HBV infection among voluntary blood donors at ten regional blood centers of HEMOPA Foundation in Pará state and to compare the residual risk of transfusion-transmitted HBV infection before and after the Brazilian HBV-NAT implementation. METHODS: The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value <0.05 was considered statistically significant. RESULTS: HBV prevalence in the periods before and after the implementation of HBV-NAT were 247 and 251 per 100,000 donations, respectively. Seroconversion rates were 114 and 122 per 100,000 donations in the two periods, respectively. The residual risk (RR) for HBV decreased significantly in the posterior period to the HBV-NAT implementation, when compared to RR before implementation, with a reduction of 1:144,92 to 1:294,11 donations (p <0,001). CONCLUSIONS: The RR to HBV decreased after the implementation of HBV-NAT, increasing significantly the transfusional security in the North region of Brazil at HEMOPA Foundation.
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spelling pubmed-63002022018-12-28 Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil Corrêa, Angelita Silva de Miranda Lamarão, Letícia Martins Vieira, Priscilla Cristina Moura de Castro, Renata Bezerra Hermes de Almeida, Núbia Caroline Costa de Castro, Jairo Augusto Américo de Lima, Maria Salete Maciel Palmeira, Mauricio Koury Meireles, Ana Luiza Langanke Pedroso Burbano, Rommel Rodríguez PLoS One Research Article BACKGROUND: Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomitant with serological tests (HBsAg and anti-HBc). This study aims to evaluate the prevalence and the incidence of HBV infection among voluntary blood donors at ten regional blood centers of HEMOPA Foundation in Pará state and to compare the residual risk of transfusion-transmitted HBV infection before and after the Brazilian HBV-NAT implementation. METHODS: The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value <0.05 was considered statistically significant. RESULTS: HBV prevalence in the periods before and after the implementation of HBV-NAT were 247 and 251 per 100,000 donations, respectively. Seroconversion rates were 114 and 122 per 100,000 donations in the two periods, respectively. The residual risk (RR) for HBV decreased significantly in the posterior period to the HBV-NAT implementation, when compared to RR before implementation, with a reduction of 1:144,92 to 1:294,11 donations (p <0,001). CONCLUSIONS: The RR to HBV decreased after the implementation of HBV-NAT, increasing significantly the transfusional security in the North region of Brazil at HEMOPA Foundation. Public Library of Science 2018-12-19 /pmc/articles/PMC6300202/ /pubmed/30566494 http://dx.doi.org/10.1371/journal.pone.0208414 Text en © 2018 Corrêa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Corrêa, Angelita Silva de Miranda
Lamarão, Letícia Martins
Vieira, Priscilla Cristina Moura
de Castro, Renata Bezerra Hermes
de Almeida, Núbia Caroline Costa
de Castro, Jairo Augusto Américo
de Lima, Maria Salete Maciel
Palmeira, Mauricio Koury
Meireles, Ana Luiza Langanke Pedroso
Burbano, Rommel Rodríguez
Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title_full Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title_fullStr Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title_full_unstemmed Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title_short Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
title_sort prevalence, incidence and residual risk of transfusion-transmitted hbv infection before and after the implementation of hbv-nat in northern brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300202/
https://www.ncbi.nlm.nih.gov/pubmed/30566494
http://dx.doi.org/10.1371/journal.pone.0208414
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