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Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore inv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300283/ https://www.ncbi.nlm.nih.gov/pubmed/30566456 http://dx.doi.org/10.1371/journal.pone.0209307 |
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author | Agyemang-Yeboah, Francis Yorke, Joseph Obirikorang, Christian Nsenbah Batu, Emmanuella Acheampong, Emmanuel Amankwaa Frimpong, Emmanuel Odame Anto, Enoch Amankwaa, Bright |
author_facet | Agyemang-Yeboah, Francis Yorke, Joseph Obirikorang, Christian Nsenbah Batu, Emmanuella Acheampong, Emmanuel Amankwaa Frimpong, Emmanuel Odame Anto, Enoch Amankwaa, Bright |
author_sort | Agyemang-Yeboah, Francis |
collection | PubMed |
description | BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana. METHODOLOGY: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained using the Kaplan–Meier method and compared by the Log-rank test. Cox regression analysis was used to assess prognostic factors. All analyses were performed by SPSS version 22. RESULTS: The median survival time was 15 months 95% CI (11.79–18.21). The overall survival rate for CRC over the 5 years period was 16.0%. The survival rates at the 1(st), 2(nd), 3(rd), 4(th) and 5(th) years were 64% 95% CI (56.2–71.1), 40% 95% CI (32.2–50.1), 21% 95% CI (11.4–30.6) 16% 95% CI (8.9–26.9) and 16% 95% CI (7.3–24.9). There was a significant difference in the survival rate of colorectal cancer according to the different stages (p = 0.0001). Family history [HR = (3.44), p = 0.029)], Chemotherapy [HR = (0.23), p = <0.0001)], BMI [HR = (1.78), p = 0.017)] and both chemo/radiotherapy (HR = (3.63), p = 0.042)] were the significant social and clinical factors influencing the overall survival. Pathological factors such as TNM tumour stage (p = 0.012), depth of tumour invasion (p = 0.036), lymph node metastasis (p = 0.0001), and distance metastasis (p = 0.001) were significantly associated with overall survival. CONCLUSION: The study has clearly demonstrated that survival rate for CRC patients at KATH, Ghana is very low in a 5 years period. This is influenced by significant number of clinical and pathological prognostic factors. Identification of prognostic factors would be a primary basis for early prediction and treatment of patients with colorectal cancer. |
format | Online Article Text |
id | pubmed-6300283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63002832018-12-28 Colorectal cancer survival rates in Ghana: A retrospective hospital-based study Agyemang-Yeboah, Francis Yorke, Joseph Obirikorang, Christian Nsenbah Batu, Emmanuella Acheampong, Emmanuel Amankwaa Frimpong, Emmanuel Odame Anto, Enoch Amankwaa, Bright PLoS One Research Article BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana. METHODOLOGY: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained using the Kaplan–Meier method and compared by the Log-rank test. Cox regression analysis was used to assess prognostic factors. All analyses were performed by SPSS version 22. RESULTS: The median survival time was 15 months 95% CI (11.79–18.21). The overall survival rate for CRC over the 5 years period was 16.0%. The survival rates at the 1(st), 2(nd), 3(rd), 4(th) and 5(th) years were 64% 95% CI (56.2–71.1), 40% 95% CI (32.2–50.1), 21% 95% CI (11.4–30.6) 16% 95% CI (8.9–26.9) and 16% 95% CI (7.3–24.9). There was a significant difference in the survival rate of colorectal cancer according to the different stages (p = 0.0001). Family history [HR = (3.44), p = 0.029)], Chemotherapy [HR = (0.23), p = <0.0001)], BMI [HR = (1.78), p = 0.017)] and both chemo/radiotherapy (HR = (3.63), p = 0.042)] were the significant social and clinical factors influencing the overall survival. Pathological factors such as TNM tumour stage (p = 0.012), depth of tumour invasion (p = 0.036), lymph node metastasis (p = 0.0001), and distance metastasis (p = 0.001) were significantly associated with overall survival. CONCLUSION: The study has clearly demonstrated that survival rate for CRC patients at KATH, Ghana is very low in a 5 years period. This is influenced by significant number of clinical and pathological prognostic factors. Identification of prognostic factors would be a primary basis for early prediction and treatment of patients with colorectal cancer. Public Library of Science 2018-12-19 /pmc/articles/PMC6300283/ /pubmed/30566456 http://dx.doi.org/10.1371/journal.pone.0209307 Text en © 2018 Agyemang-Yeboah et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Agyemang-Yeboah, Francis Yorke, Joseph Obirikorang, Christian Nsenbah Batu, Emmanuella Acheampong, Emmanuel Amankwaa Frimpong, Emmanuel Odame Anto, Enoch Amankwaa, Bright Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title | Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title_full | Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title_fullStr | Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title_full_unstemmed | Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title_short | Colorectal cancer survival rates in Ghana: A retrospective hospital-based study |
title_sort | colorectal cancer survival rates in ghana: a retrospective hospital-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300283/ https://www.ncbi.nlm.nih.gov/pubmed/30566456 http://dx.doi.org/10.1371/journal.pone.0209307 |
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