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Colorectal cancer survival rates in Ghana: A retrospective hospital-based study

BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore inv...

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Autores principales: Agyemang-Yeboah, Francis, Yorke, Joseph, Obirikorang, Christian, Nsenbah Batu, Emmanuella, Acheampong, Emmanuel, Amankwaa Frimpong, Emmanuel, Odame Anto, Enoch, Amankwaa, Bright
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300283/
https://www.ncbi.nlm.nih.gov/pubmed/30566456
http://dx.doi.org/10.1371/journal.pone.0209307
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author Agyemang-Yeboah, Francis
Yorke, Joseph
Obirikorang, Christian
Nsenbah Batu, Emmanuella
Acheampong, Emmanuel
Amankwaa Frimpong, Emmanuel
Odame Anto, Enoch
Amankwaa, Bright
author_facet Agyemang-Yeboah, Francis
Yorke, Joseph
Obirikorang, Christian
Nsenbah Batu, Emmanuella
Acheampong, Emmanuel
Amankwaa Frimpong, Emmanuel
Odame Anto, Enoch
Amankwaa, Bright
author_sort Agyemang-Yeboah, Francis
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana. METHODOLOGY: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained using the Kaplan–Meier method and compared by the Log-rank test. Cox regression analysis was used to assess prognostic factors. All analyses were performed by SPSS version 22. RESULTS: The median survival time was 15 months 95% CI (11.79–18.21). The overall survival rate for CRC over the 5 years period was 16.0%. The survival rates at the 1(st), 2(nd), 3(rd), 4(th) and 5(th) years were 64% 95% CI (56.2–71.1), 40% 95% CI (32.2–50.1), 21% 95% CI (11.4–30.6) 16% 95% CI (8.9–26.9) and 16% 95% CI (7.3–24.9). There was a significant difference in the survival rate of colorectal cancer according to the different stages (p = 0.0001). Family history [HR = (3.44), p = 0.029)], Chemotherapy [HR = (0.23), p = <0.0001)], BMI [HR = (1.78), p = 0.017)] and both chemo/radiotherapy (HR = (3.63), p = 0.042)] were the significant social and clinical factors influencing the overall survival. Pathological factors such as TNM tumour stage (p = 0.012), depth of tumour invasion (p = 0.036), lymph node metastasis (p = 0.0001), and distance metastasis (p = 0.001) were significantly associated with overall survival. CONCLUSION: The study has clearly demonstrated that survival rate for CRC patients at KATH, Ghana is very low in a 5 years period. This is influenced by significant number of clinical and pathological prognostic factors. Identification of prognostic factors would be a primary basis for early prediction and treatment of patients with colorectal cancer.
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spelling pubmed-63002832018-12-28 Colorectal cancer survival rates in Ghana: A retrospective hospital-based study Agyemang-Yeboah, Francis Yorke, Joseph Obirikorang, Christian Nsenbah Batu, Emmanuella Acheampong, Emmanuel Amankwaa Frimpong, Emmanuel Odame Anto, Enoch Amankwaa, Bright PLoS One Research Article BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana. METHODOLOGY: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained using the Kaplan–Meier method and compared by the Log-rank test. Cox regression analysis was used to assess prognostic factors. All analyses were performed by SPSS version 22. RESULTS: The median survival time was 15 months 95% CI (11.79–18.21). The overall survival rate for CRC over the 5 years period was 16.0%. The survival rates at the 1(st), 2(nd), 3(rd), 4(th) and 5(th) years were 64% 95% CI (56.2–71.1), 40% 95% CI (32.2–50.1), 21% 95% CI (11.4–30.6) 16% 95% CI (8.9–26.9) and 16% 95% CI (7.3–24.9). There was a significant difference in the survival rate of colorectal cancer according to the different stages (p = 0.0001). Family history [HR = (3.44), p = 0.029)], Chemotherapy [HR = (0.23), p = <0.0001)], BMI [HR = (1.78), p = 0.017)] and both chemo/radiotherapy (HR = (3.63), p = 0.042)] were the significant social and clinical factors influencing the overall survival. Pathological factors such as TNM tumour stage (p = 0.012), depth of tumour invasion (p = 0.036), lymph node metastasis (p = 0.0001), and distance metastasis (p = 0.001) were significantly associated with overall survival. CONCLUSION: The study has clearly demonstrated that survival rate for CRC patients at KATH, Ghana is very low in a 5 years period. This is influenced by significant number of clinical and pathological prognostic factors. Identification of prognostic factors would be a primary basis for early prediction and treatment of patients with colorectal cancer. Public Library of Science 2018-12-19 /pmc/articles/PMC6300283/ /pubmed/30566456 http://dx.doi.org/10.1371/journal.pone.0209307 Text en © 2018 Agyemang-Yeboah et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Agyemang-Yeboah, Francis
Yorke, Joseph
Obirikorang, Christian
Nsenbah Batu, Emmanuella
Acheampong, Emmanuel
Amankwaa Frimpong, Emmanuel
Odame Anto, Enoch
Amankwaa, Bright
Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title_full Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title_fullStr Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title_full_unstemmed Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title_short Colorectal cancer survival rates in Ghana: A retrospective hospital-based study
title_sort colorectal cancer survival rates in ghana: a retrospective hospital-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300283/
https://www.ncbi.nlm.nih.gov/pubmed/30566456
http://dx.doi.org/10.1371/journal.pone.0209307
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