Cargando…
Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients
OBJECTIVES: There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. METHODS: This is a...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300286/ https://www.ncbi.nlm.nih.gov/pubmed/30566451 http://dx.doi.org/10.1371/journal.pone.0208240 |
_version_ | 1783381650764201984 |
---|---|
author | Dargham, Soha R. Zahirovic, Sumeja Hammoudeh, Mohammed Al Emadi, Samar Masri, Basel K. Halabi, Hussein Badsha, Humeira Uthman, Imad Mahfoud, Ziyad R. Ashour, Hadil Gad El Haq, Wissam Bayoumy, Karim Kapiri, Marianthi Saxena, Richa Plenge, Robert M. Kazkaz, Layla Arayssi, Thurayya |
author_facet | Dargham, Soha R. Zahirovic, Sumeja Hammoudeh, Mohammed Al Emadi, Samar Masri, Basel K. Halabi, Hussein Badsha, Humeira Uthman, Imad Mahfoud, Ziyad R. Ashour, Hadil Gad El Haq, Wissam Bayoumy, Karim Kapiri, Marianthi Saxena, Richa Plenge, Robert M. Kazkaz, Layla Arayssi, Thurayya |
author_sort | Dargham, Soha R. |
collection | PubMed |
description | OBJECTIVES: There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. METHODS: This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. RESULTS: The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). CONCLUSION: Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients. |
format | Online Article Text |
id | pubmed-6300286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63002862018-12-28 Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients Dargham, Soha R. Zahirovic, Sumeja Hammoudeh, Mohammed Al Emadi, Samar Masri, Basel K. Halabi, Hussein Badsha, Humeira Uthman, Imad Mahfoud, Ziyad R. Ashour, Hadil Gad El Haq, Wissam Bayoumy, Karim Kapiri, Marianthi Saxena, Richa Plenge, Robert M. Kazkaz, Layla Arayssi, Thurayya PLoS One Research Article OBJECTIVES: There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the demographic characteristics, clinical profile, and treatment patterns of patients of Arab ancestry with RA. METHODS: This is a cross sectional study of 895 patients with established rheumatoid arthritis enrolled from five sites (Jordan, Lebanon, Qatar, Kingdom of Saudi Arabia (KSA), and United Arab Emirates). Demographic characteristics, clinical profile, and treatment patterns are compared between the five countries. RESULTS: The majority of our patients are women, have an average disease duration of 10 years, are married and non-smokers, with completed secondary education. We report a high (>80%) ever-use of methotrexate (MTX) and steroids among our RA population, while the ever-use of disease modifying anti-rheumatic drugs (DMARDs) and TNF-inhibitors average around 67% and 33%, respectively. There are variations in RA treatment use between the five country sites. Highest utilization of steroids is identified in Jordan and KSA (p-value < 0.001), while the highest ever-use of TNF-inhibitors is reported in KSA (p-value < 0.001). CONCLUSION: Disparities in usage of RA treatments among Arab patients are noted across the five countries. National gross domestic product (GDP), as well as some other unique features in each country likely affect these. Developing treatment guidelines specific to this region could contribute in delivering standardized therapies to RA patients. Public Library of Science 2018-12-19 /pmc/articles/PMC6300286/ /pubmed/30566451 http://dx.doi.org/10.1371/journal.pone.0208240 Text en © 2018 Dargham et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dargham, Soha R. Zahirovic, Sumeja Hammoudeh, Mohammed Al Emadi, Samar Masri, Basel K. Halabi, Hussein Badsha, Humeira Uthman, Imad Mahfoud, Ziyad R. Ashour, Hadil Gad El Haq, Wissam Bayoumy, Karim Kapiri, Marianthi Saxena, Richa Plenge, Robert M. Kazkaz, Layla Arayssi, Thurayya Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title | Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title_full | Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title_fullStr | Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title_full_unstemmed | Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title_short | Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients |
title_sort | epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of arab patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300286/ https://www.ncbi.nlm.nih.gov/pubmed/30566451 http://dx.doi.org/10.1371/journal.pone.0208240 |
work_keys_str_mv | AT darghamsohar epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT zahirovicsumeja epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT hammoudehmohammed epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT alemadisamar epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT masribaselk epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT halabihussein epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT badshahumeira epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT uthmanimad epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT mahfoudziyadr epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT ashourhadil epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT gadelhaqwissam epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT bayoumykarim epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT kapirimarianthi epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT saxenaricha epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT plengerobertm epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT kazkazlayla epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients AT arayssithurayya epidemiologyandtreatmentpatternsofrheumatoidarthritisinalargecohortofarabpatients |