Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

Titin, the largest protein known, forms an elastic myofilament in the striated muscle sarcomere. To establish titin’s contribution to skeletal muscle passive stiffness, relative to that of the extracellular matrix, a mouse model was created in which titin’s molecular spring region was shortened by d...

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Detalles Bibliográficos
Autores principales: Brynnel, Ambjorn, Hernandez, Yaeren, Kiss, Balazs, Lindqvist, Johan, Adler, Maya, Kolb, Justin, van der Pijl, Robbert, Gohlke, Jochen, Strom, Joshua, Smith, John, Ottenheijm, Coen, Granzier, Henk L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Physics of Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300359/
https://www.ncbi.nlm.nih.gov/pubmed/30565562
http://dx.doi.org/10.7554/eLife.40532

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