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A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation
BACKGROUND: Neuropathic pain is a common and intractable sequel of brachial plexus injury. MATERIALS AND METHODS: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury. RESULTS: Behavioral test of mechanical st...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300374/ https://www.ncbi.nlm.nih.gov/pubmed/30588069 http://dx.doi.org/10.2147/JPR.S174663 |
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author | Hou, Ao-Lin Xu, Wen-Dong |
author_facet | Hou, Ao-Lin Xu, Wen-Dong |
author_sort | Hou, Ao-Lin |
collection | PubMed |
description | BACKGROUND: Neuropathic pain is a common and intractable sequel of brachial plexus injury. MATERIALS AND METHODS: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury. RESULTS: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it. CONCLUSION: The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain. |
format | Online Article Text |
id | pubmed-6300374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63003742018-12-26 A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation Hou, Ao-Lin Xu, Wen-Dong J Pain Res Original Research BACKGROUND: Neuropathic pain is a common and intractable sequel of brachial plexus injury. MATERIALS AND METHODS: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury. RESULTS: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it. CONCLUSION: The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain. Dove Medical Press 2018-12-13 /pmc/articles/PMC6300374/ /pubmed/30588069 http://dx.doi.org/10.2147/JPR.S174663 Text en © 2018 Hou and Xu. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hou, Ao-Lin Xu, Wen-Dong A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title | A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title_full | A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title_fullStr | A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title_full_unstemmed | A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title_short | A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
title_sort | model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300374/ https://www.ncbi.nlm.nih.gov/pubmed/30588069 http://dx.doi.org/10.2147/JPR.S174663 |
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