Cell type–dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance

Studies of drug resistance mostly characterize genetic mutation, and we know much less about phenotypic mechanisms of drug resistance, especially at a quantitative level. p53 is an important mediator of cellular response to chemotherapy, but even p53 wild-type cells vary in drug sensitivity for uncl...

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Detalles Bibliográficos
Autores principales: Yang, Ruizhen, Huang, Bo, Zhu, Yanting, Li, Yang, Liu, Feng, Shi, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300403/
https://www.ncbi.nlm.nih.gov/pubmed/30585287
http://dx.doi.org/10.1126/sciadv.aat5077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300403/
https://www.ncbi.nlm.nih.gov/pubmed/30585287
http://dx.doi.org/10.1126/sciadv.aat5077

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