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Cell type–dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance
Studies of drug resistance mostly characterize genetic mutation, and we know much less about phenotypic mechanisms of drug resistance, especially at a quantitative level. p53 is an important mediator of cellular response to chemotherapy, but even p53 wild-type cells vary in drug sensitivity for uncl...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300403/ https://www.ncbi.nlm.nih.gov/pubmed/30585287 http://dx.doi.org/10.1126/sciadv.aat5077 |