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Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders
Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative diseas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300566/ https://www.ncbi.nlm.nih.gov/pubmed/30618562 http://dx.doi.org/10.3389/fnins.2018.00933 |
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author | Ge, Weihao Jakobsson, Eric |
author_facet | Ge, Weihao Jakobsson, Eric |
author_sort | Ge, Weihao |
collection | PubMed |
description | Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative disease, showing that understanding lithium action is of high importance. In this paper we undertake first steps toward a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with affective and neurodegenerative disorders. This work integrates information from two important databases, STRING and KEGG pathways. We find that for the majority of neurodegenerative disorders the mutual enrichment is many times greater than chance, reinforcing previous lines of evidence that lithium is an important influence on incidence of neurodegeneration. Our work suggests rational prioritization for which disorders are likely to be most sensitive to lithium and identifies genes that are likely to be useful targets for therapy adjunct to lithium. |
format | Online Article Text |
id | pubmed-6300566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63005662019-01-07 Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders Ge, Weihao Jakobsson, Eric Front Neurosci Neuroscience Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative disease, showing that understanding lithium action is of high importance. In this paper we undertake first steps toward a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with affective and neurodegenerative disorders. This work integrates information from two important databases, STRING and KEGG pathways. We find that for the majority of neurodegenerative disorders the mutual enrichment is many times greater than chance, reinforcing previous lines of evidence that lithium is an important influence on incidence of neurodegeneration. Our work suggests rational prioritization for which disorders are likely to be most sensitive to lithium and identifies genes that are likely to be useful targets for therapy adjunct to lithium. Frontiers Media S.A. 2018-12-13 /pmc/articles/PMC6300566/ /pubmed/30618562 http://dx.doi.org/10.3389/fnins.2018.00933 Text en Copyright © 2018 Ge and Jakobsson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ge, Weihao Jakobsson, Eric Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title_full | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title_fullStr | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title_full_unstemmed | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title_short | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
title_sort | systems biology understanding of the effects of lithium on affective and neurodegenerative disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300566/ https://www.ncbi.nlm.nih.gov/pubmed/30618562 http://dx.doi.org/10.3389/fnins.2018.00933 |
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