Roles of Pericytes in Stroke Pathogenesis

Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. As perivascular multi-potent cells and an important com...

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Detalles Bibliográficos
Autores principales: Gautam, Jyoti, Yao, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300777/
https://www.ncbi.nlm.nih.gov/pubmed/29845887
http://dx.doi.org/10.1177/0963689718768455
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author Gautam, Jyoti
Yao, Yao
author_facet Gautam, Jyoti
Yao, Yao
author_sort Gautam, Jyoti
collection PubMed
description Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. As perivascular multi-potent cells and an important component of the blood–brain barrier (BBB), pericytes have been shown to exert a large variety of functions, including serving as stem/progenitor cells and maintaining BBB integrity. Here in this review, we summarize the roles of pericytes in stroke pathogenesis, with a focus on their effects in cerebral blood flow, BBB integrity, angiogenesis, immune responses, scar formation and fibrosis.
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spelling pubmed-63007772019-01-07 Roles of Pericytes in Stroke Pathogenesis Gautam, Jyoti Yao, Yao Cell Transplant Original Articles Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. As perivascular multi-potent cells and an important component of the blood–brain barrier (BBB), pericytes have been shown to exert a large variety of functions, including serving as stem/progenitor cells and maintaining BBB integrity. Here in this review, we summarize the roles of pericytes in stroke pathogenesis, with a focus on their effects in cerebral blood flow, BBB integrity, angiogenesis, immune responses, scar formation and fibrosis. SAGE Publications 2018-05-30 2018-12 /pmc/articles/PMC6300777/ /pubmed/29845887 http://dx.doi.org/10.1177/0963689718768455 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Gautam, Jyoti
Yao, Yao
Roles of Pericytes in Stroke Pathogenesis
title Roles of Pericytes in Stroke Pathogenesis
title_full Roles of Pericytes in Stroke Pathogenesis
title_fullStr Roles of Pericytes in Stroke Pathogenesis
title_full_unstemmed Roles of Pericytes in Stroke Pathogenesis
title_short Roles of Pericytes in Stroke Pathogenesis
title_sort roles of pericytes in stroke pathogenesis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300777/
https://www.ncbi.nlm.nih.gov/pubmed/29845887
http://dx.doi.org/10.1177/0963689718768455
work_keys_str_mv AT gautamjyoti rolesofpericytesinstrokepathogenesis
AT yaoyao rolesofpericytesinstrokepathogenesis

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