The Protective Role of Crocus Sativus L. (Saffron) Against Ischemia-Reperfusion Injury, Hyperlipidemia and Atherosclerosis: Nature Opposing Cardiovascular Diseases

BACKGROUND: Reactive oxygen species and reactive nitrogen species, which are collective-ly called reactive oxygen-nitrogen species, are inevitable by-products of cellular metabolic redox reac-tions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reac-tions of biotransformation of exogenous and endogenous substrate in endoplasmic reticulum, eico-sanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medici-nal plants, there is growing interest in Crocus Sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Tur-key, Iran, India, China, Egypt and Mexico. OBJECTIVE: The present study aims to address the anti-toxicant role of Crocus Sativus L. in the case of cardiovascular disease and its role towards the cardioprotective role of Crocus Sativus L. Materials and METHODS: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to deter-mine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. RESULTS: Our review has indicated that scientific literature confirms the role of Crocus Sativus L. as a cardiovascular-protective agent. The literature review showed that Saffron is a potent cardiovascular-protective agent with a plethora of applications ranging from ischemia-reperfusion injury, diabetes and hypertension to hyperlipidemia. CONCLUSION: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as a cardiovascular-protective agent and in particular, Crocus Sativus L. manifests beneficial results against ischemia-reperfusion injury, hypertension, hy-perlipidemia and diabetes