Cargando…

Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein

Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors α (ESR1) and β (ESR2). With regard to hematological malignancies, expression of ESR2 has been found in both B and T cell lymphomas. In addition to endogenous estrogens or selective ESR2 agonists, ESR2 signa...

Descripción completa

Detalles Bibliográficos
Autores principales: Yakimchuk, Konstantin, Bangalore Revanna, Chandrashekar, Huang, Dan, Inzunza, Jose, Okret, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300865/
https://www.ncbi.nlm.nih.gov/pubmed/30496125
http://dx.doi.org/10.1530/EC-18-0459
_version_ 1783381757520773120
author Yakimchuk, Konstantin
Bangalore Revanna, Chandrashekar
Huang, Dan
Inzunza, Jose
Okret, Sam
author_facet Yakimchuk, Konstantin
Bangalore Revanna, Chandrashekar
Huang, Dan
Inzunza, Jose
Okret, Sam
author_sort Yakimchuk, Konstantin
collection PubMed
description Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors α (ESR1) and β (ESR2). With regard to hematological malignancies, expression of ESR2 has been found in both B and T cell lymphomas. In addition to endogenous estrogens or selective ESR2 agonists, ESR2 signaling may be affected by both environmental synthetic estrogen-mimicking compounds and dietary phytoestrogens. In the present study, we demonstrate that oral exposure with either the synthetic compound bisphenol A (BPA) or the dietary phytoestrogen genistein reduced the growth of grafted murine T cell (EG7) and human B cell (Granta-519 mantle cell) lymphomas which both express ESR2. Suppression of lymphoma growth was due to reduced proliferation (BPA and genistein) and induction of apoptosis (genistein). Inhibition of lymphoma growth was seen at a BPA dose of 50 µg/kg body weight (BW)/day considered to be safe human exposure dose or a genistein dose of 1 mg/kg BW/day orally, which is reached in soy-rich diets. Thus, our study indicates that the environmental xenoestrogens BPA and genistein have anti-proliferative effects on ESR2-expressing lymphomas. Our data suggest that phytoestrogens may be considered as a dietary supplement for lymphoma patients and possibly for prevention of lymphoid malignancies.
format Online
Article
Text
id pubmed-6300865
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-63008652018-12-26 Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein Yakimchuk, Konstantin Bangalore Revanna, Chandrashekar Huang, Dan Inzunza, Jose Okret, Sam Endocr Connect Research Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors α (ESR1) and β (ESR2). With regard to hematological malignancies, expression of ESR2 has been found in both B and T cell lymphomas. In addition to endogenous estrogens or selective ESR2 agonists, ESR2 signaling may be affected by both environmental synthetic estrogen-mimicking compounds and dietary phytoestrogens. In the present study, we demonstrate that oral exposure with either the synthetic compound bisphenol A (BPA) or the dietary phytoestrogen genistein reduced the growth of grafted murine T cell (EG7) and human B cell (Granta-519 mantle cell) lymphomas which both express ESR2. Suppression of lymphoma growth was due to reduced proliferation (BPA and genistein) and induction of apoptosis (genistein). Inhibition of lymphoma growth was seen at a BPA dose of 50 µg/kg body weight (BW)/day considered to be safe human exposure dose or a genistein dose of 1 mg/kg BW/day orally, which is reached in soy-rich diets. Thus, our study indicates that the environmental xenoestrogens BPA and genistein have anti-proliferative effects on ESR2-expressing lymphomas. Our data suggest that phytoestrogens may be considered as a dietary supplement for lymphoma patients and possibly for prevention of lymphoid malignancies. Bioscientifica Ltd 2018-11-23 /pmc/articles/PMC6300865/ /pubmed/30496125 http://dx.doi.org/10.1530/EC-18-0459 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Yakimchuk, Konstantin
Bangalore Revanna, Chandrashekar
Huang, Dan
Inzunza, Jose
Okret, Sam
Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title_full Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title_fullStr Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title_full_unstemmed Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title_short Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
title_sort suppression of lymphoma growth by the xenoestrogens bisphenol a and genistein
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300865/
https://www.ncbi.nlm.nih.gov/pubmed/30496125
http://dx.doi.org/10.1530/EC-18-0459
work_keys_str_mv AT yakimchukkonstantin suppressionoflymphomagrowthbythexenoestrogensbisphenolaandgenistein
AT bangalorerevannachandrashekar suppressionoflymphomagrowthbythexenoestrogensbisphenolaandgenistein
AT huangdan suppressionoflymphomagrowthbythexenoestrogensbisphenolaandgenistein
AT inzunzajose suppressionoflymphomagrowthbythexenoestrogensbisphenolaandgenistein
AT okretsam suppressionoflymphomagrowthbythexenoestrogensbisphenolaandgenistein