In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

BACKGROUND: Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is different in several steps when compared with the human ho...

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Detalles Bibliográficos
Autores principales: de Sena Pereira, Valeska S., da Silva Emery, Flávio, Lobo, Lis, Nogueira, Fátima, Oliveira, Jonas I. N., Fulco, Umberto L., Albuquerque, Eudenilson L., Katzin, Alejandro M., de Andrade-Neto, Valter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300878/
https://www.ncbi.nlm.nih.gov/pubmed/30567541
http://dx.doi.org/10.1186/s12936-018-2615-8

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