The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus

OBJECTIVE: To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) METHODS: This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on gl...

Descripción completa

Detalles Bibliográficos
Autores principales: Higashikawa, Toshihiro, Ito, Tomohiko, Mizuno, Takurou, Ishigami, Keiichirou, Kohori, Masaru, Mae, Kunihiro, Sangen, Ryusho, Usuda, Daisuke, Saito, Atsushi, Iguchi, Masaharu, Kasamaki, Yuji, Fukuda, Akihiro, Saito, Hitoshi, Kanda, Tsugiyasu, Okuro, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Clinical Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300940/
https://www.ncbi.nlm.nih.gov/pubmed/30354916
http://dx.doi.org/10.1177/0300060518790870
_version_ 1783381773734903808
author Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takurou
Ishigami, Keiichirou
Kohori, Masaru
Mae, Kunihiro
Sangen, Ryusho
Usuda, Daisuke
Saito, Atsushi
Iguchi, Masaharu
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Kanda, Tsugiyasu
Okuro, Masashi
author_facet Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takurou
Ishigami, Keiichirou
Kohori, Masaru
Mae, Kunihiro
Sangen, Ryusho
Usuda, Daisuke
Saito, Atsushi
Iguchi, Masaharu
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Kanda, Tsugiyasu
Okuro, Masashi
author_sort Higashikawa, Toshihiro
collection PubMed
description OBJECTIVE: To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) METHODS: This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. RESULTS: Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. CONCLUSION: This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration.
format Online
Article
Text
id pubmed-6300940
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-63009402019-01-11 The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus Higashikawa, Toshihiro Ito, Tomohiko Mizuno, Takurou Ishigami, Keiichirou Kohori, Masaru Mae, Kunihiro Sangen, Ryusho Usuda, Daisuke Saito, Atsushi Iguchi, Masaharu Kasamaki, Yuji Fukuda, Akihiro Saito, Hitoshi Kanda, Tsugiyasu Okuro, Masashi J Int Med Res Clinical Research Reports OBJECTIVE: To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) METHODS: This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. RESULTS: Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. CONCLUSION: This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration. SAGE Publications 2018-10-25 2018-12 /pmc/articles/PMC6300940/ /pubmed/30354916 http://dx.doi.org/10.1177/0300060518790870 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takurou
Ishigami, Keiichirou
Kohori, Masaru
Mae, Kunihiro
Sangen, Ryusho
Usuda, Daisuke
Saito, Atsushi
Iguchi, Masaharu
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Kanda, Tsugiyasu
Okuro, Masashi
The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title_full The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title_fullStr The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title_full_unstemmed The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title_short The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
title_sort effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly japanese patients with type 2 diabetes mellitus
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300940/
https://www.ncbi.nlm.nih.gov/pubmed/30354916
http://dx.doi.org/10.1177/0300060518790870
work_keys_str_mv AT higashikawatoshihiro theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT itotomohiko theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT mizunotakurou theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT ishigamikeiichirou theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kohorimasaru theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT maekunihiro theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT sangenryusho theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT usudadaisuke theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT saitoatsushi theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT iguchimasaharu theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kasamakiyuji theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT fukudaakihiro theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT saitohitoshi theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kandatsugiyasu theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT okuromasashi theeffectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT higashikawatoshihiro effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT itotomohiko effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT mizunotakurou effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT ishigamikeiichirou effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kohorimasaru effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT maekunihiro effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT sangenryusho effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT usudadaisuke effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT saitoatsushi effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT iguchimasaharu effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kasamakiyuji effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT fukudaakihiro effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT saitohitoshi effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT kandatsugiyasu effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus
AT okuromasashi effectsof12monthadministrationoftofogliflozinonelectrolytesanddehydrationinmainlyelderlyjapanesepatientswithtype2diabetesmellitus

Ejemplares similares