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Structure-guided combination therapy to potently improve the function of mutant CFTRs

Available drugs are unable to effectively rescue the folding defects in vitro and ameliorate the clinical-phenotype of cystic fibrosis (CF), caused by deletion of F508 (ΔF508 or F508del) and some point mutations in the CF transmembrane conductance regulator (CFTR), a plasma membrane (PM) anion chann...

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Detalles Bibliográficos
Autores principales:	Veit, Guido, Xu, Haijin, Dreano, Elise, Avramescu, Radu G, Bagdany, Miklos, Beitel, Lenore K, Roldan, Ariel, Hancock, Mark A, Lay, Cecilia, Li, Wei, Morin, Katelin, Gao, Sandra, Mak, Puiying A, Ainscow, Edward, Orth, Anthony P, McNamara, Peter, Edelman, Aleksander, Frenkiel, Saul, Matouk, Elias, Sermet-Gaudelus, Isabelle, Barnes, William G, Lukacs, Gergely L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301090/ https://www.ncbi.nlm.nih.gov/pubmed/30297908 http://dx.doi.org/10.1038/s41591-018-0200-x

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