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Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for select...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301150/ https://www.ncbi.nlm.nih.gov/pubmed/29915241 http://dx.doi.org/10.1038/s41370-018-0048-7 |
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author | Barry, Vaughn Klein, Mitchel Winquist, Andrea Chang, Howard H. Mulholland, James A. Talbott, Evelyn O. Rager, Judith R. Tolbert, Paige E. Sarnat, Stefanie Ebelt |
author_facet | Barry, Vaughn Klein, Mitchel Winquist, Andrea Chang, Howard H. Mulholland, James A. Talbott, Evelyn O. Rager, Judith R. Tolbert, Paige E. Sarnat, Stefanie Ebelt |
author_sort | Barry, Vaughn |
collection | PubMed |
description | Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for selected respiratory outcomes in 5 U.S. cities under various model assumptions and assessed model fit. Population-weighted average 8-hr maximum O(3) concentrations were estimated in each city. Individual-level data on ED visits were obtained from hospitals or hospital associations. Poisson log-linear models were used to estimate city-specific associations between the daily number of respiratory ED visits and 3- day moving average O(3) levels controlling for long-term trends and meteorology. Linear, linear-threshold, quadratic, cubic, categorical, and cubic spline O(3) C-R models were considered. Using linear C-R models, O3 was significantly and positively associated with respiratory ED visits in each city with rate ratios of 1.02-1.07 per 25 ppb. Models suggested that O(3)-ED C-R shapes were linear until O(3) concentrations of roughly 60 ppb at which point risk continued to increase linearly in some cities for certain outcomes while risk flattened in others. Assessing C-R shape is necessary to identify the most appropriate form of the exposure for each given study setting. |
format | Online Article Text |
id | pubmed-6301150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-63011502019-02-20 Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities Barry, Vaughn Klein, Mitchel Winquist, Andrea Chang, Howard H. Mulholland, James A. Talbott, Evelyn O. Rager, Judith R. Tolbert, Paige E. Sarnat, Stefanie Ebelt J Expo Sci Environ Epidemiol Article Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for selected respiratory outcomes in 5 U.S. cities under various model assumptions and assessed model fit. Population-weighted average 8-hr maximum O(3) concentrations were estimated in each city. Individual-level data on ED visits were obtained from hospitals or hospital associations. Poisson log-linear models were used to estimate city-specific associations between the daily number of respiratory ED visits and 3- day moving average O(3) levels controlling for long-term trends and meteorology. Linear, linear-threshold, quadratic, cubic, categorical, and cubic spline O(3) C-R models were considered. Using linear C-R models, O3 was significantly and positively associated with respiratory ED visits in each city with rate ratios of 1.02-1.07 per 25 ppb. Models suggested that O(3)-ED C-R shapes were linear until O(3) concentrations of roughly 60 ppb at which point risk continued to increase linearly in some cities for certain outcomes while risk flattened in others. Assessing C-R shape is necessary to identify the most appropriate form of the exposure for each given study setting. 2018-06-19 2019-03 /pmc/articles/PMC6301150/ /pubmed/29915241 http://dx.doi.org/10.1038/s41370-018-0048-7 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Barry, Vaughn Klein, Mitchel Winquist, Andrea Chang, Howard H. Mulholland, James A. Talbott, Evelyn O. Rager, Judith R. Tolbert, Paige E. Sarnat, Stefanie Ebelt Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title | Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title_full | Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title_fullStr | Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title_full_unstemmed | Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title_short | Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities |
title_sort | characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 u.s. cities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301150/ https://www.ncbi.nlm.nih.gov/pubmed/29915241 http://dx.doi.org/10.1038/s41370-018-0048-7 |
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