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Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities

Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for select...

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Autores principales: Barry, Vaughn, Klein, Mitchel, Winquist, Andrea, Chang, Howard H., Mulholland, James A., Talbott, Evelyn O., Rager, Judith R., Tolbert, Paige E., Sarnat, Stefanie Ebelt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301150/
https://www.ncbi.nlm.nih.gov/pubmed/29915241
http://dx.doi.org/10.1038/s41370-018-0048-7
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author Barry, Vaughn
Klein, Mitchel
Winquist, Andrea
Chang, Howard H.
Mulholland, James A.
Talbott, Evelyn O.
Rager, Judith R.
Tolbert, Paige E.
Sarnat, Stefanie Ebelt
author_facet Barry, Vaughn
Klein, Mitchel
Winquist, Andrea
Chang, Howard H.
Mulholland, James A.
Talbott, Evelyn O.
Rager, Judith R.
Tolbert, Paige E.
Sarnat, Stefanie Ebelt
author_sort Barry, Vaughn
collection PubMed
description Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for selected respiratory outcomes in 5 U.S. cities under various model assumptions and assessed model fit. Population-weighted average 8-hr maximum O(3) concentrations were estimated in each city. Individual-level data on ED visits were obtained from hospitals or hospital associations. Poisson log-linear models were used to estimate city-specific associations between the daily number of respiratory ED visits and 3- day moving average O(3) levels controlling for long-term trends and meteorology. Linear, linear-threshold, quadratic, cubic, categorical, and cubic spline O(3) C-R models were considered. Using linear C-R models, O3 was significantly and positively associated with respiratory ED visits in each city with rate ratios of 1.02-1.07 per 25 ppb. Models suggested that O(3)-ED C-R shapes were linear until O(3) concentrations of roughly 60 ppb at which point risk continued to increase linearly in some cities for certain outcomes while risk flattened in others. Assessing C-R shape is necessary to identify the most appropriate form of the exposure for each given study setting.
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spelling pubmed-63011502019-02-20 Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities Barry, Vaughn Klein, Mitchel Winquist, Andrea Chang, Howard H. Mulholland, James A. Talbott, Evelyn O. Rager, Judith R. Tolbert, Paige E. Sarnat, Stefanie Ebelt J Expo Sci Environ Epidemiol Article Although short-term exposure to ambient ozone (O(3)) can cause poor respiratory health outcomes, the shape of the concentration-response (C-R) between O(3) and respiratory morbidity has not been widely investigated. We estimated the effect of daily O(3) on emergency department (ED) visits for selected respiratory outcomes in 5 U.S. cities under various model assumptions and assessed model fit. Population-weighted average 8-hr maximum O(3) concentrations were estimated in each city. Individual-level data on ED visits were obtained from hospitals or hospital associations. Poisson log-linear models were used to estimate city-specific associations between the daily number of respiratory ED visits and 3- day moving average O(3) levels controlling for long-term trends and meteorology. Linear, linear-threshold, quadratic, cubic, categorical, and cubic spline O(3) C-R models were considered. Using linear C-R models, O3 was significantly and positively associated with respiratory ED visits in each city with rate ratios of 1.02-1.07 per 25 ppb. Models suggested that O(3)-ED C-R shapes were linear until O(3) concentrations of roughly 60 ppb at which point risk continued to increase linearly in some cities for certain outcomes while risk flattened in others. Assessing C-R shape is necessary to identify the most appropriate form of the exposure for each given study setting. 2018-06-19 2019-03 /pmc/articles/PMC6301150/ /pubmed/29915241 http://dx.doi.org/10.1038/s41370-018-0048-7 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Barry, Vaughn
Klein, Mitchel
Winquist, Andrea
Chang, Howard H.
Mulholland, James A.
Talbott, Evelyn O.
Rager, Judith R.
Tolbert, Paige E.
Sarnat, Stefanie Ebelt
Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title_full Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title_fullStr Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title_full_unstemmed Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title_short Characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 U.S. cities
title_sort characterization of the concentration-response curve for ambient ozone and acute respiratory morbidity in 5 u.s. cities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301150/
https://www.ncbi.nlm.nih.gov/pubmed/29915241
http://dx.doi.org/10.1038/s41370-018-0048-7
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