Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential...

Descripción completa

Detalles Bibliográficos
Autores principales: Veale, Clinton G. L., Hoppe, Heinrich C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301270/
https://www.ncbi.nlm.nih.gov/pubmed/30647879
http://dx.doi.org/10.1039/c8md00319j
_version_ 1783381804969885696
author Veale, Clinton G. L.
Hoppe, Heinrich C.
author_facet Veale, Clinton G. L.
Hoppe, Heinrich C.
author_sort Veale, Clinton G. L.
collection PubMed
description This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.
format Online
Article
Text
id pubmed-6301270
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-63012702019-10-26 Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery Veale, Clinton G. L. Hoppe, Heinrich C. Medchemcomm Chemistry This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation. Royal Society of Chemistry 2018-10-26 /pmc/articles/PMC6301270/ /pubmed/30647879 http://dx.doi.org/10.1039/c8md00319j Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Veale, Clinton G. L.
Hoppe, Heinrich C.
Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title_full Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title_fullStr Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title_full_unstemmed Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title_short Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery
title_sort screening of the pathogen box reveals new starting points for anti-trypanosomal drug discovery
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301270/
https://www.ncbi.nlm.nih.gov/pubmed/30647879
http://dx.doi.org/10.1039/c8md00319j
work_keys_str_mv AT vealeclintongl screeningofthepathogenboxrevealsnewstartingpointsforantitrypanosomaldrugdiscovery
AT hoppeheinrichc screeningofthepathogenboxrevealsnewstartingpointsforantitrypanosomaldrugdiscovery

Ejemplares similares