Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology

Olmesartan-associated enteropathy (OAE) is increasingly being recognised as a major differential diagnosis in patients with villous atrophy and negative coeliac disease (CD) serology. OAE and positive coeliac markers have rarely been reported. We report a case of diarrhoea and small bowel villous bl...

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Detalles Bibliográficos
Autores principales: Ghaith, Jenan, Raslan, Ismail A, Szilagyi, Andrew, Alameldin, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Unusual Presentation of More Common Disease/Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301511/
https://www.ncbi.nlm.nih.gov/pubmed/30567230
http://dx.doi.org/10.1136/bcr-2018-225518
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author Ghaith, Jenan
Raslan, Ismail A
Szilagyi, Andrew
Alameldin, Mona
author_facet Ghaith, Jenan
Raslan, Ismail A
Szilagyi, Andrew
Alameldin, Mona
author_sort Ghaith, Jenan
collection PubMed
description Olmesartan-associated enteropathy (OAE) is increasingly being recognised as a major differential diagnosis in patients with villous atrophy and negative coeliac disease (CD) serology. OAE and positive coeliac markers have rarely been reported. We report a case of diarrhoea and small bowel villous blunting associated with a transient elevation of antitissue transglutaminase antibody (ATTG). On discontinuation of olmesartan, symptoms improved, repeat biopsies were normal and levels of ATTG also returned normal. We discuss a possible explanation for the transient elevation in ATTG and the significance of considering OAE/CD overlap.
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spelling pubmed-63015112019-01-04 Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology Ghaith, Jenan Raslan, Ismail A Szilagyi, Andrew Alameldin, Mona BMJ Case Rep Unusual Presentation of More Common Disease/Injury Olmesartan-associated enteropathy (OAE) is increasingly being recognised as a major differential diagnosis in patients with villous atrophy and negative coeliac disease (CD) serology. OAE and positive coeliac markers have rarely been reported. We report a case of diarrhoea and small bowel villous blunting associated with a transient elevation of antitissue transglutaminase antibody (ATTG). On discontinuation of olmesartan, symptoms improved, repeat biopsies were normal and levels of ATTG also returned normal. We discuss a possible explanation for the transient elevation in ATTG and the significance of considering OAE/CD overlap. BMJ Publishing Group 2018-12-13 /pmc/articles/PMC6301511/ /pubmed/30567230 http://dx.doi.org/10.1136/bcr-2018-225518 Text en © BMJ Publishing Group Limited 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Unusual Presentation of More Common Disease/Injury
Ghaith, Jenan
Raslan, Ismail A
Szilagyi, Andrew
Alameldin, Mona
Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title_full Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title_fullStr Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title_full_unstemmed Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title_short Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
title_sort case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
topic Unusual Presentation of More Common Disease/Injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301511/
https://www.ncbi.nlm.nih.gov/pubmed/30567230
http://dx.doi.org/10.1136/bcr-2018-225518
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