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GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era

The genetic variability of Infectious bronchitis virus (IBV) is one of the main challenges for its control, hindering not only the development of effective vaccination strategies but also its classification and, consequently, epidemiology understanding. The 624/I and Q1 genotypes, now recognized to...

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Autores principales: Franzo, Giovanni, Cecchinato, Mattia, Tosi, Giovanni, Fiorentini, Laura, Faccin, Francesca, Tucciarone, Claudia Maria, Trogu, Tiziana, Barbieri, Ilaria, Massi, Paola, Moreno, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301571/
https://www.ncbi.nlm.nih.gov/pubmed/30571679
http://dx.doi.org/10.1371/journal.pone.0203513
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author Franzo, Giovanni
Cecchinato, Mattia
Tosi, Giovanni
Fiorentini, Laura
Faccin, Francesca
Tucciarone, Claudia Maria
Trogu, Tiziana
Barbieri, Ilaria
Massi, Paola
Moreno, Ana
author_facet Franzo, Giovanni
Cecchinato, Mattia
Tosi, Giovanni
Fiorentini, Laura
Faccin, Francesca
Tucciarone, Claudia Maria
Trogu, Tiziana
Barbieri, Ilaria
Massi, Paola
Moreno, Ana
author_sort Franzo, Giovanni
collection PubMed
description The genetic variability of Infectious bronchitis virus (IBV) is one of the main challenges for its control, hindering not only the development of effective vaccination strategies but also its classification and, consequently, epidemiology understanding. The 624/I and Q1 genotypes, now recognized to be part of the GI-16 lineage, represent an excellent example of the practical consequences of IBV molecular epidemiology limited knowledge. In fact, being their common origin unrecognized for a long time, independent epidemiological pictures were drawn for the two genotypes. To fix this misinterpretation, the present study reconstructs the history, population dynamics and spreading patterns of GI-16 lineage as a whole using a phylodynamic approach. A collection of worldwide available hypervariable region 1 and 2 (HVR12) and 3 (HVR3) sequences of the S1 protein was analysed together with 258 HVR3 sequences obtained from samples collected in Italy (the country where this genotype was initially identified) since 1963. The results demonstrate that after its emergence at the beginning of the XX century, GI-16 was able to persist until present days in Italy. Approximately in the late 1980s, it migrated to Asia, which became the main nucleus for further spreading to Middle East, Europe and especially South America, likely through multiple introduction events. A remarkable among-country diffusion was also demonstrated in Asia and South America. Interestingly, although most of the recent Italian GI-16 strains originated from ancestral viruses detected in the same country, a couple were closely related to Chinese ones, supporting a backward viral flow from China to Italy. Besides to the specific case-study results, this work highlights the misconceptions that originate from the lack of a unified nomenclature and poor molecular epidemiology data generation and sharing. This shortcoming appears particularly relevant since the described scenario could likely be shared by many other IBV genotypes and pathogens in general.
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spelling pubmed-63015712018-12-31 GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era Franzo, Giovanni Cecchinato, Mattia Tosi, Giovanni Fiorentini, Laura Faccin, Francesca Tucciarone, Claudia Maria Trogu, Tiziana Barbieri, Ilaria Massi, Paola Moreno, Ana PLoS One Research Article The genetic variability of Infectious bronchitis virus (IBV) is one of the main challenges for its control, hindering not only the development of effective vaccination strategies but also its classification and, consequently, epidemiology understanding. The 624/I and Q1 genotypes, now recognized to be part of the GI-16 lineage, represent an excellent example of the practical consequences of IBV molecular epidemiology limited knowledge. In fact, being their common origin unrecognized for a long time, independent epidemiological pictures were drawn for the two genotypes. To fix this misinterpretation, the present study reconstructs the history, population dynamics and spreading patterns of GI-16 lineage as a whole using a phylodynamic approach. A collection of worldwide available hypervariable region 1 and 2 (HVR12) and 3 (HVR3) sequences of the S1 protein was analysed together with 258 HVR3 sequences obtained from samples collected in Italy (the country where this genotype was initially identified) since 1963. The results demonstrate that after its emergence at the beginning of the XX century, GI-16 was able to persist until present days in Italy. Approximately in the late 1980s, it migrated to Asia, which became the main nucleus for further spreading to Middle East, Europe and especially South America, likely through multiple introduction events. A remarkable among-country diffusion was also demonstrated in Asia and South America. Interestingly, although most of the recent Italian GI-16 strains originated from ancestral viruses detected in the same country, a couple were closely related to Chinese ones, supporting a backward viral flow from China to Italy. Besides to the specific case-study results, this work highlights the misconceptions that originate from the lack of a unified nomenclature and poor molecular epidemiology data generation and sharing. This shortcoming appears particularly relevant since the described scenario could likely be shared by many other IBV genotypes and pathogens in general. Public Library of Science 2018-12-20 /pmc/articles/PMC6301571/ /pubmed/30571679 http://dx.doi.org/10.1371/journal.pone.0203513 Text en © 2018 Franzo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Franzo, Giovanni
Cecchinato, Mattia
Tosi, Giovanni
Fiorentini, Laura
Faccin, Francesca
Tucciarone, Claudia Maria
Trogu, Tiziana
Barbieri, Ilaria
Massi, Paola
Moreno, Ana
GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title_full GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title_fullStr GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title_full_unstemmed GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title_short GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era
title_sort gi-16 lineage (624/i or q1), there and back again: the history of one of the major threats for poultry farming of our era
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301571/
https://www.ncbi.nlm.nih.gov/pubmed/30571679
http://dx.doi.org/10.1371/journal.pone.0203513
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