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Neurofibromin haploinsufficiency results in altered spermatogenesis in a mouse model of neurofibromatosis type 1

The fertility of men with neurofibromatosis 1 (NF1) is reduced. Despite this observation, gonadal function has not been examined in patients with NF1. In order to assess the role of reduced neurofibromin in the testes, we examined testicular morphology and function in an Nf1(+/-) mouse model. We fou...

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Detalles Bibliográficos
Autores principales:	Chohan, Harleen, Esfandiarei, Mitra, Arman, Darian, Van Raamsdonk, Catherine D., van Breemen, Cornelis, Friedman, Jan M., Jett, Kimberly A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301684/ https://www.ncbi.nlm.nih.gov/pubmed/30571760 http://dx.doi.org/10.1371/journal.pone.0208835

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